Large cell neuroendocrine carcinoma of the nasopharynx: A case report

被引：7

作者：

Elloumi, F. ^{[1
]}

Fourati, N. ^{[1
]}

Siala, W. ^{[1
]}

Ghorbell, L. ^{[1
]}

Jlidi, R. ^{[1
]}

Ghorbel, A. ^{[2
]}

Frikha, M. ^{[3
]}

Daoud, J. ^{[1
]}

机构：

[1] CHU Habib Bourguiba, Serv Radiotherapie Oncol, Sfax, Tunisia

[2] CHU Habib Bourguiba, Serv ORL, Sfax, Tunisia

[3] CHU Habib Bourguiba, Serv Carcinol Med, Sfax, Tunisia

来源：

CANCER RADIOTHERAPIE | 2014年 / 18卷 / 03期

关键词：

Large cell neuroendocrine carcinoma; Nasopharynx; Carcinoma; HEAD; NECK; LUNG;

D O I：

10.1016/j.canrad.2014.03.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neuroendocrine carcinoma of the head and neck is a rare entity. The parotid gland is the most commonly affected site. A nasopharyngeal site has not been previously described. We report a 35-year-old patient who consulted for tinnitus and nasal obstruction. The assessment found a nasopharyngeal tumour T4N0M0. The patient underwent 6 cycles of chemotherapy based on VP16 and cisplatin, followed by radiotherapy at a dose of 70 Gy to the nasopharynx and 50 Gy to the neck. The evolution was marked by clinical improvement and radiological stability. Six months after the end of treatment, the patient had a local and meningeal relapse. He received palliative care. He died 19 months after the end of treatment. 2014 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.

引用

页码：208 / 210

页数：3

共 10 条

[1] Management of nonsinonasal neuroendocrine carcinomas of the head and neck
Barker, JL
Glisson, BS
Garden, AS
El-Naggar, AK
Morrison, WH
Ang, KK
Chao, KSC
Clayman, G
Rosenthal, DI
[J]. CANCER, 2003, 98 (11) : 2322 - 2328
[2] Brambilla E., 2004, World Health Organization Classification of Tumours Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart, P45
[3] Large cell neuroendocrine carcinoma of the larynx: a case report and a review of the classification of this neoplasm
Greene, L
Brundage, W
Cooper, K
[J]. JOURNAL OF CLINICAL PATHOLOGY, 2005, 58 (06) : 658 - 661
[4] UNDIFFERENTIATED CARCINOMAS OF THE MAJOR SALIVARY-GLANDS
HUI, KK
LUNA, MA
BATSAKIS, JG
ORDONEZ, NG
WEBER, R
[J]. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 1990, 69 (01): : 76 - 83
[5] Mucosal large cell neuroendocrine carcinoma of the head and neck regions in Japanese patients: a distinct clinicopathological entity
Kusafuka, Kimihide
Abe, Masato
Iida, Yoshiyuki
Onitsuka, Tetsuro
Fuke, Tomohito
Asano, Rei
Kamijo, Tomoyuki
Nakajima, Takashi
[J]. JOURNAL OF CLINICAL PATHOLOGY, 2012, 65 (08) : 704 - 709
[6] Large cell neuroendocrine carcinoma of the head and neck
Kusafuka, Kimihide
Ferlito, Alfio
Lewis, James S., Jr.
Woolgar, Julia A.
Rinaldo, Alessandra
Slootweg, Pieter J.
Gnepp, Douglas R.
Devaney, Kenneth O.
Travis, William D.
Barnes, Leon
[J]. ORAL ONCOLOGY, 2012, 48 (03) : 211 - 215
[7] Large cell neuroendocrine carcinoma of the Larynx: Definition of an entity
Lewis Jr. J.S.
Spence D.C.
Chiosea S.
Barnes Jr. E.L.
Brandwein-Gensler M.
El-Mofty S.K.
[J]. Head and Neck Pathology, 2010, 4 (3) : 198 - 207
[8] Rekhtman N, 2010, ARCH PATHOL LAB MED, V134, P1628, DOI 10.1043/2009-0583-RAR.1
[9] Shunyu N Brian., 2012, Clinical Rhinology, V5, P130, DOI [10.5005/jp-journals-10013-1134, DOI 10.5005/JP-JOURNALS-10013-1134]
[10] Should Large Cell Neuroendocrine Lung Carcinoma be Classified and Treated as a Small Cell Lung Cancer or with Other Large Cell Carcinomas?
Varlotto, John M.
Medford-Davis, Laura Nyshel
Recht, Abram
Flickinger, John C.
Schaefer, Eric
Zander, Dani S.
DeCamp, Malcolm M.
[J]. JOURNAL OF THORACIC ONCOLOGY, 2011, 6 (06) : 1050 - 1058

← 1 →