A novel bilayer drug-loaded wound dressing of PVDF and PHB/Chitosan nanofibers applicable for post-surgical ulcers

被引：67

作者：

Amini, Fatemeh ^{[1
]}

Semnani, Dariush ^{[1
]}

Karbasi, Saeed ^{[2
]}

Banitaba, Seyedeh Nooshin ^{[1
]}

机构：

[1] Isfahan Univ Technol, Dept Text Engn, Esfahan 8415683111, Iran

[2] Isfahan Univ Med Sci, Sch Adv Technol Med, Dept Biomat & Tissue Engn, Esfahan, Iran

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2019年 / 68卷 / 13期

关键词：

Drug-loaded nanofibers; nanofiber; post-surgical ulcer; wound dressing; ELECTROSPUN NANOFIBERS; DELIVERY; RELEASE; ANTIBACTERIAL; MEMBRANE; CHITOSAN; SCAFFOLD; ALCOHOL;

D O I：

10.1080/00914037.2018.1506982

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A novel bilayer nanofibrous wound dressing, with enhanced mechanical properties is successfully fabricated. This membrane, consisted of polyvinylidenefluoride (PVDF) nanofibers for providing tensile strength and polyhydroxybutyrate/chitosan (PHB/CTS) nanofibers loaded with gentamicin with ability of controlled drug delivery, is a great choice for post-surgical ulcers. Mechanical properties showed dramatically improvement of tensile strength by addition of PVDF layer. Gentamycin release represented both an immediate and a sustained release of about 24 h and 1 week, respectively and release increment with increase of CTS ratio. Results also revealed that drug release in structures follow first order kinetic and Fickian release mechanism.

引用

页码：772 / 777

页数：6

共 30 条

[21] Dissolution and absorption modeling: Model expansion to simulate the effects of precipitation, water absorption, longitudinally changing intestinal permeability, and controlled release on drug absorption [J].