DOPAMINERGIC PROJECTIONS TO THE MEDIAL PREOPTIC AREA OF POSTPARTUM RATS

被引:41
|
作者
Miller, S. M. [2 ]
Lonstein, J. S. [1 ,2 ]
机构
[1] Michigan State Univ, Neurosci Program, E Lansing, MI 48824 USA
[2] Michigan State Univ, Dept Psychol, Behav Neurosci Program, E Lansing, MI 48824 USA
关键词
catecholamine; dopamine; female; maternal behavior; postpartum; ANTEROVENTRAL PERIVENTRICULAR NUCLEUS; VENTRAL TEGMENTAL AREA; HYDROXYLASE-IMMUNOREACTIVE NEURONS; POSTERIOR HYPOTHALAMIC-LESIONS; CENTRAL-NERVOUS-SYSTEM; PHA-L ANALYSIS; MATERNAL-BEHAVIOR; SUPRAMAMMILLARY NUCLEUS; BASAL FOREBRAIN; SEXUAL-BEHAVIOR;
D O I
10.1016/j.neuroscience.2009.01.060
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Dopamine receptor activity in the rodent medial preoptic area (mPOA) is crucial for the display of maternal behaviors, as well as numerous other physiological and behavioral functions. However, the origin of dopaminergic input to the mPOA has not been identified through neuroanatomical tracing. To accomplish this, the retrograde tracer Fluorogold was iontophoretically applied to the mPOA of postpartum laboratory rats, and dual-label immunocytochemistry for Fluorogold and tyrosine hydroxylase later performed to identify dopaminergic cells of the forebrain and midbrain projecting to the mPOA. Results indicate that the number of dopaminergic cells projecting to the mPOA is moderate (similar to 90 cells to one hemisphere), and that these cells have an unexpectedly wide distribution. Even so, more than half of the dual-labeled cells were found in either what has been considered extensions of the A10 dopamine group (particularly the ventrocaudal posterior hypothalamus and adjacent medial supramammillary nucleus), or in the A10 group of the ventral tegmental area. The rostral hypothalamus and surrounding region also contained numerous dual-labeled cells, with the greatest number found within the mPOA itself (including in the anteroventral preoptic area and preoptic periventricular nucleus). Notably, dual-labeled cells were rare in the zona incerta (A13), a site previously suggested to provide dopaminergic input to the mPOA. This study is the first to use anatomical tracing to detail the dopaminergic projections to the mPOA in the laboratory rat, and indicates that much of this projection originates more caudally than previously suggested. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:1384 / 1396
页数:13
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