An Efficient Biginelli One-Pot Synthesis of New Benzoxazole-Substituted Dihydropyrimidinones and Thiones Catalysed by Alumina-Supported Trifluoromethane Sulfonic Acid Under Solvent Free Conditions

被引：16

作者：

Arjun, M. ^{[2
]}

Sridhar, D. ^{[2
]}

Chari, M. Adharvana ^{[3
]}

Sarangapani, M. ^{[1
]}

机构：

[1] Kakatiya Univ, Dept Chem, Warangal 506009, Andhra Pradesh, India

[2] Kakatiya Univ, Univ Coll Pharmaceut Sci, Warangal 506009, Andhra Pradesh, India

[3] Kyung Hee Univ, Dept Appl Chem, Seoul, South Korea

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2009年 / 46卷 / 01期

关键词：

CALCIUM-CHANNEL BLOCKERS; HIGH-YIELD SYNTHESIS; ANTIHYPERTENSIVE AGENTS; HETEROGENEOUS CATALYST; MICROWAVE IRRADIATION; SILICA; ESTERS; DERIVATIVES; PYRIMIDINES; PROTOCOL;

D O I：

10.1002/jhet.29

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of benzoxazole-substituted 3,4-dihydropyrimidinones (DHPMs) using alumina supported trifluoromethane sulfonic acid as the catalyst for the first time from an aldehyde, P-keto ester, and benzoxazole-substituted urea and thiourea under solvent-free conditions is described. When compared with the classical Biginelli reaction conditions, this new method consistently has the advantage of excellent yields (80-93%) and short reaction time (30-120 Minutes) at 120 degrees C temperature.

引用

页码：119 / 123

页数：5

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