The Mystery of EVP4593: Perspectives of the Quinazoline-Derived Compound in the Treatment of Huntington's Disease and Other Human Pathologies

被引：3

作者：

Grekhnev, Dmitriy A. ^{[1
]}

Kruchinina, Anna A. ^{[1
]}

Vigont, Vladimir A. ^{[1
]}

Kaznacheyeva, Elena V. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Cytol, Dept Mol Physiol Cell, Lab Ion Channels Cell Membranes, 4 Tikhoretsky Ave, St Petersburg 194064, Russia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 24期

基金：

俄罗斯科学基金会;

关键词：

quinazoline derivatives; QNZ; EVP4593; calcium signaling; NF-kappa B signaling; store-operated calcium entry; Huntington's disease; huntingtin; neurodegeneration; oncology; NF-KAPPA-B; OPERATED CALCIUM-ENTRY; CA2+ ENTRY; THERAPEUTIC TARGET; POTENT INHIBITORS; STRUCTURAL CLASS; ACTIVATION; CELLS; COMPLEX; HOMEOSTASIS;

D O I：

10.3390/ijms232415724

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Quinazoline derivatives have various pharmacological activities and are widely used in clinical practice. Here, we reviewed the proposed mechanisms of the physiological activity of the quinazoline derivative EVP4593 and perspectives for its clinical implication. We summarized the accumulated data about EVP4593 and focused on its activities in different models of Huntington's disease (HD), including patient-specific iPSCs-based neurons. To make a deeper insight into its neuroprotective role in HD treatment, we discussed the ability of EVP4593 to modulate calcium signaling and reduce the level of the huntingtin protein. Moreover, we described possible protective effects of EVP4593 in other pathologies, such as oncology, cardiovascular diseases and parasite invasion. We hope that comprehensive analyses of the molecular mechanisms of EVP4593 activity will allow for the expansion of the scope of the EVP4593 application.

引用

页数：13

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