Efficient Synthesis and Evaluation of Quorum-Sensing Modulators Using Small Molecule Macroarrays

被引：40

作者：

Praneenararat, Thanit ^{[1
]}

Geske, Grant D. ^{[1
]}

Blackwell, Helen E. ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 20期

关键词：

GRAM-NEGATIVE BACTERIA; ACYLATED HOMOSERINE LACTONES; CHROMOBACTERIUM-VIOLACEUM; CELL COMMUNICATION; SPOT-SYNTHESIS; IDENTIFICATION; AUTOINDUCERS; MECHANISMS;

D O I：

10.1021/ol901871y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for the synthesis of small molecule macroarrays of N-acylated L-homoserine lactones (AHLs) is reported. A focused library of AHLs was constructed, and the macroarray platform was found to be compatible with both solution and agar-overlay assays using quorum-sensing (QS) reporter strains. Several QS antagonists were discovered and serve to showcase the macroarray as a straightforward technique for QS research.

引用

页码：4600 / 4603

页数：4

共 20 条

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