A New Flavanone from Seeds of Psoralea corylifolia with α-Glucosidase Inhibitory Activity

被引：1

作者：

Liu, Ying ^{[1
,2
]}

Dong, Jia-Yue ^{[3
]}

Ren, Bo ^{[3
]}

机构：

[1] Sichuan Univ, West China Hosp 2, Dept Pediat, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu 610041, Sichuan, Peoples R China

[3] Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610041, Sichuan, Peoples R China

来源：

NATURAL PRODUCT COMMUNICATIONS | 2018年 / 13卷 / 07期

关键词：

Psoralea corylifolia; Type; 2; diabetes; Flavanone; alpha-Glucosidase; METABOLITES; FLAVONOIDS; FRUITS;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new flavanone (2S)-7,4'-hydroxyl-6-(2",3"-epoxy-3"-methylbutyl)flavanone (1), together with five known compounds (2-6) were isolated from EtOAcsoluble extract of seeds of Psoralea corylifolia. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All compounds were evaluated for in vitro inhibitory activity against a-glucosidase. Among them, new compound 1 was found to exhibit inhibitory activity on alpha-glucosidase with IC50 value of 29.2 mu M.

引用

页码：841 / 843

页数：3

共 13 条

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