A New Flavanone from Seeds of Psoralea corylifolia with α-Glucosidase Inhibitory Activity

被引：1
作者：
Liu, Ying [1 ,2 ]
Dong, Jia-Yue [3 ]
Ren, Bo [3 ]
机构：
[1] Sichuan Univ, West China Hosp 2, Dept Pediat, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu 610041, Sichuan, Peoples R China
[3] Chengdu Univ Tradit Chinese Med, Coll Pharm, Chengdu 610041, Sichuan, Peoples R China
来源：
NATURAL PRODUCT COMMUNICATIONS | 2018年 / 13卷 / 07期
关键词：
Psoralea corylifolia; Type; 2; diabetes; Flavanone; alpha-Glucosidase; METABOLITES; FLAVONOIDS; FRUITS;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new flavanone (2S)-7,4'-hydroxyl-6-(2",3"-epoxy-3"-methylbutyl)flavanone (1), together with five known compounds (2-6) were isolated from EtOAcsoluble extract of seeds of Psoralea corylifolia. Their structures were elucidated on the basis of spectroscopic and physico-chemical analyses. All compounds were evaluated for in vitro inhibitory activity against a-glucosidase. Among them, new compound 1 was found to exhibit inhibitory activity on alpha-glucosidase with IC50 value of 29.2 mu M.
引用
收藏
页码：841 / 843
页数：3
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