Evaluation of of the frequency of invariant natural killer T (iNKT) cells in nasal polyps

被引：2

作者：

Fereidouni, Mohammad ^{[1
,2
]}

Derakhshani, Afshin ^{[3
,4
]}

Yue, Simon ^{[5
,6
]}

Nasseri, Saeed ^{[1
]}

Hosseini, Reza Farid ^{[7
]}

Bakhshaee, Mehdi ^{[8
]}

Vahidian, Fatemeh ^{[4
]}

Exley, Mark A. ^{[5
,6
,9
]}

机构：

[1] Birjand Univ Med Sci, Cellular & Mol Res Ctr, Birjand, Iran

[2] Birjand Univ Med Sci, Sch Med, Asthma Allergy & Immunol Res Ctr, Birjand, Iran

[3] Birjand Univ Med Sci, Student Res Comm, Birjand, Iran

[4] Tabriz Univ Med Sci, Dept Immunol, Tabriz, Iran

[5] Brigham & Womens Hosp, Div Gastroenterol Endoscopy & Hepatol, 75 Francis St, Boston, MA 02115 USA

[6] Harvard Med Sch, Boston, MA 02115 USA

[7] Mashhad Univ Med Sci, Immunol Dept, Mashhad, Razavi Khorasan, Iran

[8] Mashhad Univ Med Sci, Imam Reza Educ Hosp, Dept Otorhinolaryngol Head & Neck Surg, Mashhad, Razavi Khorasan, Iran

[9] Univ Manchester, Manchester Collaborat Ctr Inflammat Res, Manchester, Lancs, England

来源：

CLINICAL IMMUNOLOGY | 2019年 / 205卷

关键词：

Invariant natural killer T-cells; NKT; Nasal polyp; Flow cytometry; Th2; EOSINOPHILIC AIRWAY INFLAMMATION; CHRONIC RHINOSINUSITIS; MONOCLONAL-ANTIBODY; SINUS MUCOSA; NKT CELLS; ASTHMA; CHILDREN; CYTOKINES; SUBSETS;

D O I：

10.1016/j.clim.2019.05.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nasal polyps (NP) are associated with inflamed mucosa of unknown etiology. The role of T cells in nasal polyposis is unclear. Invariant natural killer T cells (iNKT) can promote Th2 responses and have been implicated in some types of asthma. As there are shared inflammatory pathways involved in asthma and NPs, we evaluated the frequency of iNKT in 17 patients with NPs, but without asthma. A median of 6% polyp cells were T lymphocytes, of which iNKT were 0 to 2.38% (mean 0.674%). In the matched group (n = 10), iNKT in NPs was significantly higher than PBMCs (1.057% vs 0.155%, P < 0.05). Relative expression of V alpha 24 to TCR-beta genes in polyps (n = 14) was higher than blood in matched samples (n = 4). The presence of greater proportions of iNKT in NPs than in blood suggests that iNKT may play a role in the pathogenesis of nasal polyposis.

引用

页码：125 / 129

页数：5

共 53 条

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