Flexible DNA junction assisted efficient construction of stable gene nanoparticles for gene delivery

被引：7
作者：
Liu, Jianbing [1 ]
Li, Yanyan [1 ]
Ma, Dejun [1 ]
Ouyang, Di [1 ]
Xi, Zhen [1 ]
机构：
[1] Nankai Univ, Dept Biol Chem, State Key Lab Elementoorgan Chem, Natl Engn Res Ctr Pesticide Tianjin,Collaborat In, Tianjin 300071, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 09期
关键词：
UNMETHYLATED CPG DINUCLEOTIDES; PLASMID DNA; THERAPY PROGRESS; TRANSGENE EXPRESSION; LINEAR DNA; IMMUNE-RESPONSES; NONVIRAL VECTORS; PROSPECTS; TRANSFECTION; POLYPLEX;
D O I：
10.1039/c5cc07949g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A flexible DNA junction was designed to assist the construction of stable gene nanoparticles with multiple target gene copies, which can be used as efficient gene cargo with successful expression in eukaryotic cells for gene delivery.
引用
收藏
页码：1953 / 1956
页数：4
相关论文
共 66 条
  • [1] Immune responses to gene therapy vectors: influence on vector function and effector mechanisms
    Bessis, N
    GarciaCozar, FJ
    Boissier, MC
    [J]. GENE THERAPY, 2004, 11 (Suppl 1) : S10 - S17
  • [2] Chemical modifications and bioconjugate reactions of nanomaterials for sensing, imaging, drug delivery and therapy
    Biju, Vasudevanpillai
    [J]. CHEMICAL SOCIETY REVIEWS, 2014, 43 (03) : 744 - 764
  • [3] Transcriptional silencing is associated with extensive methylation of the CMV promoter following adenoviral gene delivery to muscle
    Brooks, AR
    Harkins, RN
    Wang, PY
    Qian, HS
    Liu, PX
    Rubanyi, GM
    [J]. JOURNAL OF GENE MEDICINE, 2004, 6 (04) : 395 - 404
  • [4] Relationship between plasmid DNA topological forms and in vitro transfection
    Chancham, P
    Hughes, JA
    [J]. JOURNAL OF LIPOSOME RESEARCH, 2001, 11 (2-3) : 139 - 152
  • [5] A pH-Triggered, Fast-Responding DNA Hydrogel
    Cheng, Enjun
    Xing, Yongzheng
    Chen, Ping
    Yang, Yang
    Sun, Yawei
    Zhou, Dejian
    Xu, Lijin
    Fan, Qinghua
    Liu, Dongsheng
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (41) : 7660 - 7663
  • [6] Effect of DNA topology on the transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid complexes
    Cherng, JY
    Schuurmans-Nieuwenbroek, NME
    Jiskoot, W
    Talsma, H
    Zuidam, NJ
    Hennink, WE
    Crommelin, DJA
    [J]. JOURNAL OF CONTROLLED RELEASE, 1999, 60 (2-3) : 343 - 353
  • [7] Effect of plasmid backbone modification by different human CpG motifs on the immunogenicity of DNA vaccine vectors
    Coban, C
    Ishii, KJ
    Gursel, M
    Klinman, DM
    Kumar, N
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2005, 78 (03) : 647 - 655
  • [8] Adenovirus: The First Effective In Vivo Gene Delivery Vector
    Crystal, Ronald G.
    [J]. HUMAN GENE THERAPY, 2014, 25 (01) : 3 - 11
  • [9] Bacterial Lipopolysaccharides in Plant and Mammalian Innate Immunity
    De Castro, Cristina
    Holst, Otto
    Lanzetta, Rosa
    Parrilli, Michelangelo
    Molinaro, Antonio
    [J]. PROTEIN AND PEPTIDE LETTERS, 2012, 19 (10) : 1040 - 1044
  • [10] Gene therapy for HIV infection
    de Mendoza, Carmen
    Barreiro, Pablo
    Benitez, Laura
    Soriano, Vicente
    [J]. EXPERT OPINION ON BIOLOGICAL THERAPY, 2015, 15 (03) : 319 - 327
1234567