A genetic basis for human susceptibility to West Nile virus

被引：23
作者：
Diamond, Michael S.
Klein, Robyn S.
机构：
[1] Washington Univ, Sch Med, Dept Med, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
[4] Washington Univ, Sch Med, Dept Anat & Neurobiol, St Louis, MO 63110 USA
来源：
TRENDS IN MICROBIOLOGY | 2006年 / 14卷 / 07期
关键词：
D O I：
10.1016/j.tim.2006.05.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
West Nile virus (WNV) infects thousands of humans annually and causes a spectrum of disease ranging from an acute febrile illness to lethal encephalitis. A new study suggests a link between CCR5 Delta 32 (a common mutant allele of the chemokine and HIV receptor CCR5) and fatal WNV infection. The study highlights a possible risk in targeting this receptor for the prevention and/or treatment of infectious diseases.
引用
收藏
页码：287 / 289
页数：3
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