Assessment of 8-hydroxydeoxyguanosine levels in patients with preeclampsia: a prospective study

被引：3

作者：

Akinci, S. ^{[1
]}

Ozcan, H. C. ^{[1
]}

Balat, O. ^{[1
]}

Ugur, M. G. ^{[1
]}

Ozturk, E. ^{[2
]}

Taysi, S. ^{[3
]}

Sucu, S. ^{[4
]}

机构：

[1] Gaziantep Univ, Sch Med, Dept Obstet & Gynecol, Gaziantep, Turkey

[2] Medipol Univ, Sch Med, Dept Obstet & Gynecol, Istanbul, Turkey

[3] Gaziantep Univ, Sch Med, Dept Biochem, Gaziantep, Turkey

[4] Gaziantep Cengiz Gokcek Matern Hosp, Dept Obstet & Gynecol, Gaziantep, Turkey

来源：

CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY | 2017年 / 44卷 / 02期

关键词：

Oxidative stress; Preeclampsia; 8-hydroxydeoxyguanosine; OXIDATIVE DNA-DAMAGE; 8-HYDROXY-2'-DEOXYGUANOSINE; HYPERTENSION; PLACENTA; STRESS; REPAIR; WOMEN;

D O I：

10.12891/ceog3474.2017

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Purpose of investigation: To determine the levels of 8-hydroxydeoxyguanosine (8-OHdG) in preeclampsia (PE) using (enzyme linked immunosorbent assay (ELISA) method. Materials and Methods: Twenty-two pregnant women with severe PE, 18 pregnant women with mild PE, and 40 healthy pregnant women, all between 25 and 41 weeks of gestation, were enrolled in this prospective controlled study. 8-OHdG levels in maternal serum were measured using ELISA method. Results: The authors observed no statistically significant difference in 8-OHdG levels between the mild-severe PE and control groups (p = 0.208). Conclusion: The present results do not support the concept that 8-OHdG has a role in the etiopathogenesis of PE.

引用

页码：226 / 229

页数：4

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