Malignancies, Particularly B-Cell Lymphomas, Are a Frequent Cause of Mortality in Human Immunodeficiency Virus-1 Patients Despite Highly Active Antiretroviral Therapy

被引：7

作者：

Griffin, Daniel O. ^{[1
,2
,3
]}

Metzger, Michael ^{[4
]}

Poeth, Kaitlin ^{[3
]}

Deng, Kathy ^{[3
]}

Dharsee, Arif ^{[3
]}

Rico, Juan Carlos ^{[3
]}

McGowan, Joseph ^{[4
]}

机构：

[1] Columbia Univ, Med Ctr, Dept Biochem & Mol Biophys, HHSC 1310c,701 West 168th St, New York, NY 10032 USA

[2] Columbia Univ, Med Ctr, Div Infect Dis, Dept Med, New York, NY 10032 USA

[3] Hofstra North Shore LIJ Sch Med, Dept Med, Div Infect Dis, Manhasset, NY USA

[4] Columbia Univ, Med Ctr, Dept Biochem & Mol Biophys, Howard Hughes Med Inst, New York, NY 10032 USA

来源：

OPEN FORUM INFECTIOUS DISEASES | 2015年 / 2卷 / 04期

关键词：

B cell; HIV-1; lymphoma; malignancy; mortality; UNITED-STATES; DEATH; POPULATION; CANCER;

D O I：

10.1093/ofid/ofv147

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human immunodeficiency virus (HIV)-1-infected individuals are affected by diseases at rates above those of their HIV-negative peers despite the increased life expectancy of the highly active antiretroviral therapy era. We followed a cohort of approximately 2000 HIV-1-infected patients for 5 years. The most frequent cause of death in this HIV-1-infected cohort was malignancy, with 39% of all classified deaths due to cancer. Among the cancer deaths, B-cell lymphomas were the most commonly seen malignancy, representing 34% of all cancer deaths. These lymphomas were very aggressive with a median survival of <2 months from time of diagnosis.

引用

页数：4

共 15 条

[1]

Aberg Judith A, 2012, Top Antivir Med, V20, P101

[2] Shorter Telomere Length Predicts Poorer Immunological Recovery in Virologically Suppressed HIV-1-Infected Patients Treated With Combined Antiretroviral Therapy [J].

Blanco, Jose-Ramon ;

Jarrin, Inma ;

Martinez, Alfredo ;

Siles, Eva ;

Larrayoz, Ignacio M. ;

Canuelo, Ana ;

Gutierrez, Felix ;

Gonzalez-Garcia, Juan ;

Vidal, Francesc ;

Moreno, Santiago .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2015, 68 (01) :21-29

[3]

CDC, 2012, HIV SURVEILL S, P14

[4] Causes of Death in HIV-1-Infected Patients Treated with Antiretroviral Therapy, 1996-2006: Collaborative Analysis of 13 HIV Cohort Studies [J].

Gill, John ;

May, Margaret ;

Lewden, Charlotte ;

Saag, Mike ;

Mugavero, Michael ;

Reiss, Peter ;

Ledergerber, Bruno ;

Mocroft, Amanda ;

Harris, Ross ;

Fux, Christoph A. ;

Justice, Amy ;

Costagliola, Dominique ;

Casabona, Jordi ;

Hogg, Robert S. ;

Khaykin, Pavel ;

Lampe, Fiona ;

Vehreschild, Janne ;

Sterne, Jonathan A. C. ;

Egger, Matthias ;

Brodt, Hans-Reinhard ;

Casabona, Jordi ;

Chene, Genevieve ;

Costagliola, Dominique ;

Dabis, Francois ;

Monforte, Antonella D'Arminio ;

de Wolf, Frank ;

Faetkenheuer, Gerd ;

Gill, John ;

Guest, Jodie ;

Hogg, Robert S. ;

Justice, Amy ;

Kirk, Ole ;

Kitahata, Mari ;

Lampe, Fiona ;

Ledergerber, Bruno ;

Reiss, Peter ;

Sterling, Tim .

CLINICAL INFECTIOUS DISEASES, 2010, 50 (10) :1387-1396

[5] Life Expectancy After HIV Diagnosis Based on National HIV Surveillance Data From 25 States, United States [J].

Harrison, Kathleen McDavid ;

Song, Ruiguang ;

Zhang, Xinjian .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2010, 53 (01) :124-130

[6]

Horvath S, 2015, J INFECT DIS

[7] Causes of death in the HAART era [J].

Lucas, Sebastian .

CURRENT OPINION IN INFECTIOUS DISEASES, 2012, 25 (01) :36-41

[8] Chronic immune activation and inflammation as the cause of malignancy [J].

O'Byrne, KJ ;

Dalgleish, A .

BRITISH JOURNAL OF CANCER, 2001, 85 (04) :473-483

[9] Estimated HIV Incidence in the United States, 2006-2009 [J].

Prejean, Joseph ;

Song, Ruiguang ;

Hernandez, Angela ;

Ziebell, Rebecca ;

Green, Timothy ;

Walker, Frances ;

Lin, Lillian S. ;

An, Qian ;

Mermin, Jonathan ;

Lansky, Amy ;

Hall, H. Irene .

PLOS ONE, 2011, 6 (08)

[10] Acceleration of Age-Associated Methylation Patterns in HIV-1-Infected Adults [J].

Rickabaugh, Tammy M. ;

Baxter, Ruth M. ;

Sehl, Mary ;

Sinsheimer, Janet S. ;

Hultin, Patricia M. ;

Hultin, Lance E. ;

Quach, Austin ;

Martnez-Maza, Otoniel ;

Horvath, Steve ;

Vilain, Eric ;

Jamieson, Beth D. .

PLOS ONE, 2015, 10 (03)

← 1 2 →