Comparative Efficacies of Cloxacillin-Daptomycin and the Standard Cloxacillin-Rifampin Therapies against an Experimental Foreign-Body Infection by Methicillin-Susceptible Staphylococcus aureus

被引：12
作者：
El Haj, Cristina [1 ]
Murillo, Oscar [1 ]
Ribera, Alba [1 ]
Vivas, Mireia [1 ]
Garcia-Somoza, Dolors [2 ]
Tubau, Fe [2 ]
Cabo, Javier [3 ]
Ariza, Javier [1 ]
机构：
[1] Hosp Univ Bellvitge, Hosp Llobregat, Infect Dis Serv, Lab Expt Infect, Barcelona, Spain
[2] Hosp Univ Bellvitge, Hosp Llobregat, Dept Microbiol, Barcelona, Spain
[3] Hosp Univ Bellvitge, Hosp Llobregat, IDIBELL, Dept Orthoped Surg, Barcelona, Spain
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 09期
关键词：
BETA-LACTAMS; RESISTANT; ENDOCARDITIS; COMBINATION; OXACILLIN; NAFCILLIN; MODEL;
D O I：
10.1128/AAC.02681-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We compared the efficacies of daptomycin (doses equivalent to 8 to 10 mg/kg of body weight/day in humans) and cloxacillin alone with those of cloxacillin-rifampin and cloxacillin-daptomycin combinations, using a tissue cage methicillin-susceptible Staphylococcus aureus (MSSA) infection model. Monotherapies were less effective than combinations (P < 0.05), and daptomycin resistance emerged. Cloxacillin-daptomycin proved as effective as cloxacillin-rifampin and prevented the appearance of resistance; this combination may be an alternative anti-MSSA therapy, which may offer greater benefits in the early treatment of prosthetic joint infections (PJI).
引用
收藏
页码：5576 / 5580
页数：5
相关论文
共 23 条
[1]  
[Anonymous], 1999, M26A NAT COMM CLIN L
[2]   Altering the Proclivity towards Daptomycin Resistance in Methicillin-Resistant Staphylococcus aureus Using Combinations with Other Antibiotics [J].
Berti, Andrew D. ;
Wergin, Justine E. ;
Girdaukas, Gary G. ;
Hetzel, Scott J. ;
Sakoulas, George ;
Rose, Warren E. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (10) :5046-5053
[3]  
CHUARD C, 1991, J INFECT DIS, V163, P1369
[4]  
Clinical and Laboratory Standards Institute, 2009, M7A8 CLIN LAB STAND
[5]   Use of Antistaphylococcal β-Lactams to Increase Daptomycin Activity in Eradicating Persistent Bacteremia Due to Methicillin-Resistant Staphylococcus aureus: Role of Enhanced Daptomycin Binding [J].
Dhand, Abhay ;
Bayer, Arnold S. ;
Pogliano, Joseph ;
Yang, Soo-Jin ;
Bolaris, Michael ;
Nizet, Victor ;
Wang, Guiquing ;
Sakoulas, George .
CLINICAL INFECTIOUS DISEASES, 2011, 53 (02) :158-163
[6]   Efficacy of Daptomycin-Cloxacillin Combination in Experimental Foreign-Body Infection Due to Methicillin-Resistant Staphylococcus aureus [J].
Garrigos, C. ;
Murillo, O. ;
Lora-Tamayo, J. ;
Verdaguer, R. ;
Tubau, F. ;
Cabellos, C. ;
Cabo, J. ;
Ariza, J. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (07) :3806-3811
[7]   Comparison of ceftaroline fosamil, daptomycin and tigecycline in an experimental rabbit endocarditis model caused by methicillin-susceptible, methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus [J].
Jacqueline, Cedric ;
Amador, Gilles ;
Batard, Eric ;
Le Mabecque, Virginie ;
Miegeville, Anne-Francoise ;
Biek, Donald ;
Caillon, Jocelyne ;
Potel, Gilles .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2011, 66 (04) :863-866
[8]   Impact of high-inoculum Staphylococcus aureus on the activities of nafcillin, vancomycin, linezolid, and daptomycin, alone and in combination with gentamicin, in an in vitro pharmacodynamic model [J].
LaPlante, KL ;
Rybak, MJ .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (12) :4665-4672
[9]  
Liu C, 2011, CLIN INFECT DIS, V52, P285, DOI [10.1093/cid/cir034, 10.1093/cid/ciq146]
[10]   Addition of Gentamicin or Rifampin Does Not Enhance the Effectiveness of Daptomycin in Treatment of Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus [J].
Miro, J. M. ;
Garcia-de-la-Maria, C. ;
Armero, Y. ;
Soy, D. ;
Moreno, A. ;
del Rio, A. ;
Almela, M. ;
Sarasa, M. ;
Mestres, C. A. ;
Gatell, J. M. ;
Jimenez de Anta, M. T. ;
Marco, F. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (10) :4172-4177
123