Asthma and ethnic minorities: socioeconomic status and beyond

被引:141
作者
Forno, Erick [1 ,3 ,4 ]
Celedon, Juan C. [1 ,2 ,4 ]
机构
[1] Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA
[2] Brigham & Womens Hosp, Div Pulm Crit Care Med, Boston, MA 02115 USA
[3] Childrens Hosp, Dept Pediat, Div Resp Dis, Boston, MA 02115 USA
[4] Harvard Univ, Sch Med, Boston, MA USA
基金
美国国家卫生研究院;
关键词
asthma epidemiology; childhood asthma; ethnicity; minorities; race; socioeconomic status; CHILDHOOD-ASTHMA; UNITED-STATES; PUERTO-RICAN; RACIAL/ETHNIC VARIATION; COMMUNITY VIOLENCE; PROSPECTIVE COHORT; AIR-POLLUTION; ADAM33; GENE; INNER-CITY; EARLY-LIFE;
D O I
10.1097/ACI.0b013e3283292207
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Purpose of review We aim to discuss current insights into our understanding of the mechanisms by which socioeconomic status influences the prevalence and severity of asthma in ethnic minorities. In addition, we review potential risk factors for ethnic disparities in asthma that are not mediated by socioeconomic status. Recent findings Exposures and factors correlated with ethnicity through socioeconomic status (e.g. indoor and outdoor air quality, smoke exposure, and access to healthcare) are likely to explain a significant proportion of the observed ethnic differences in asthma morbidity. However, other factors correlated with ethnicity (e.g. genetic variation) can impact ethnic disparities in asthma independently of and/or interacting with socioeconomic status-related factors. Summary Socioeconomic status is a rough marker of a variety of environmental/behavioral exposures and a very important determinant of differences in asthma prevalence and severity among ethnic minorities in the United States. However, socioeconomic status is unlikely to be the sole explanation for ethnic disparities in asthma, which may also be due to differences in genetic variation and gene-by-environment interactions among ethnic groups.
引用
收藏
页码:154 / 160
页数:7
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