Towards Sequence-Controlled Antimicrobial Polymers: Effect of Polymer Block Order on Antimicrobial Activity

被引：168
作者：
Judzewitsch, Peter R. [1 ,2 ]
Thuy-Khanh Nguyen [1 ,2 ]
Shanmugam, Sivaprakash [1 ,2 ]
Wong, Edgar H. H. [1 ,2 ]
Boyer, Cyrille [1 ,2 ]
机构：
[1] UNSW Australia, Sch Chem Engn, CAMD, Sydney, NSW 2052, Australia
[2] UNSW Australia, Sch Chem Engn, ACN, Sydney, NSW 2052, Australia
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 17期
基金：
澳大利亚研究理事会;
关键词：
antimicrobial polymers; multiblock polymers; RAFT polymerisation; sequence control; LIVING RADICAL POLYMERIZATION; HOST-DEFENSE PEPTIDES; RAFT POLYMERIZATION; COPOLYMER LIBRARIES; RATIONAL DESIGN; MULTIBLOCK COPOLYMERS; HEMOLYTIC ACTIVITIES; SYNTHETIC MIMICS; HYDROPHOBICITY; ANTIBACTERIAL;
D O I：
10.1002/anie.201713036
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Synthetic polymers have shown promise in combating multidrug-resistant bacteria. However, the biological effects of sequence control in synthetic antimicrobial polymers are currently not well understood. As such, we investigate the antimicrobial effects of monomer distribution within linear high-order quasi-block copolymers consisting of aminoethyl, phenylethyl, and hydroxyethyl acrylamides made in a one-pot synthesis approach via photoinduced electron transfer-reversible addition-fragmentation chain transfer polymerisation (PET-RAFT). Through different combinations of monomer/polymer block order, antimicrobial and haemolytic activities are tuneable in a manner comparable to antimicrobial peptides.
引用
收藏
页码：4559 / 4564
页数：6
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