Design-a-trial: a rule-based decision support system for clinical trial design

被引：4

作者：

Nammuni, K ^{[1
]}

Pickering, C

Modgil, S

Montgomery, A

Hammond, P

Wyatt, JC

Altman, DG

Dunlop, R

Potts, HWW

机构：

[1] Univ Southampton, Sch Engn Sci, eSci Ctr, Southampton SO17 1BJ, Hants, England

[2] InferMed Ltd, London WC1B 3HW, England

[3] UCL, Biomed Informat Unit, Eastman Dent Inst Oral Hlth Care, London WC1B 3HW, England

[4] Natl Inst Clin Excellence, London WC1V 6NA, England

[5] Ctr Stat Med, CRUK, NHS, Inst Hlth Sci, Oxford OX3 7LF, England

[6] UCL, Ctr Hlth Informta & Multiprofess Educ, London N19 5LW, England

来源：

KNOWLEDGE-BASED SYSTEMS | 2004年 / 17卷 / 2-4期

关键词：

randomised controlled clinical trial; trial protocol; ethics application;

D O I：

10.1016/j.knosys.2004.03.007

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

The complexity of clinical research has meant that clinical trial protocols are often scientifically and ethically unsound. Trial designers often have limited statistical skills and experience in clinical research. This problem is exacerbated in the academic arena, in which access to statistical expertise is limited. Design-a-Trial (DaT) is an expert system that assists trial designers in designing and planning clinical trials. The system is developed in Visual Basic.NET and Prolog, and is due for commercial release in September 2003. The main aim of DaT is to help trial designers with limited statistical and research experience to design scientifically and ethically sound trials. It also serves as a checklist for the more experienced designers and can potentially be used to assist in the training of new clinical researchers. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：121 / 129

页数：9

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