Low, but not high, doses of melatonin entrained a free-running blind person with a long circadian period

被引：68

作者：

Lewy, AJ ^{[1
]}

Emens, JS

Sack, RL

Hasler, BP

Bernert, RA

机构：

[1] Oregon Hlth Sci Univ, Dept Psychiat, Sleep & Mood Disorders Lab, Portland, OR 97201 USA

[2] Oregon Hlth Sci Univ, Dept Ophthalmol, Portland, OR 97201 USA

[3] Oregon Hlth Sci Univ, Dept Physiol Pharmacol, Portland, OR 97201 USA

来源：

CHRONOBIOLOGY INTERNATIONAL | 2002年 / 19卷 / 03期

关键词：

circadian rhythms; free-running totally blind people; melatonin; melatonin phase-response curve;

D O I：

10.1081/CBI-120004546

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In a previous report, we were unable to entrain one out of seven totally blind people with free-running endogenous melatonin rhythms to 10 mg of exogenous melatonin. This person had the longest circadian period (24.9 h) of the group. We now find that this person can be entrained to 0.5 mg of melatonin, but not to 20 mg. These results are consistent with the idea that too much melatonin may spill over onto the wrong zone of the melatonin phase-response curve.

引用

页码：649 / 658

页数：10

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