Plasmodium vivax Infections of Duffy-Negative Erythrocytes: Historically Undetected or a Recent Adaptation?

被引：68

作者：

Gunalan, Karthigayan ^{[1
]}

Niangaly, Amadou ^{[2
]}

Thera, Mahamadou A. ^{[2
]}

Doumbo, Ogobara K. ^{[2
]}

Miller, Louis H. ^{[1
]}

机构：

[1] NIAID, Lab Malaria & Vector Res, NIH, Rockville, MD 20852 USA

[2] Univ Sci Tech & Technol Bamako, Int Ctr Excellence Res, Malaria Res & Training Ctr, Bamako, Mali

来源：

TRENDS IN PARASITOLOGY | 2018年 / 34卷 / 05期

基金：

美国国家卫生研究院;

关键词：

RICH ANTIGEN PVTRAG38; BLOOD-GROUP; BINDING-PROTEIN; MALARIA; RECEPTOR; INVASION; KNOWLESI; REVEALS; IDENTIFICATION; INDIVIDUALS;

D O I：

10.1016/j.pt.2018.02.006

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Plasmodium vivax is the main cause of malarial disease in Asia and South America. Plasmodium vivax infection was thought to be absent in African populations who are Duffy blood group antigen negative (Duffy-negative). However, many cases of P. vivax infection have recently been observed in Duffy-negative Africans. This raises the question: were P. vivax infections in Duffy-negative populations previously missed or has P. vivax adapted to infect Duffy-negative populations? This review focuses on recent P. vivax findings in Africa and reports views on the parasite ligands that may play a role in Duffy-negative P. vivax infections. In addition, clues gained from studying P. vivax infection of reticulocytes are presented, which may provide possible avenues for establishing P. vivax culture in vitro.

引用

页码：420 / 429

页数：10