Mesenchymal to epithelial transition in sarcomas

被引：47
|
作者：
Yang, Jilong [1 ]
Du, Xiaoling [2 ]
Wang, Guowen [3 ]
Sun, Yan [4 ]
Chen, Kexin [5 ]
Zhu, Xiongzeng [6 ]
Lazar, Alexander J. F. [7 ]
Hunt, Kelly K. [8 ]
Pollock, Raphael E. [8 ]
Zhang, Wei [7 ]
机构：
[1] Tianjin Med Univ, Canc Inst & Hosp, Natl Clin Canc Res Ctr, Dept Bone & Soft Tissue Tumors, Tianjin 300060, Peoples R China
[2] Tianjin Med Univ, Dept Diagnost, Tianjin 300060, Peoples R China
[3] Tianjin Med Univ, Canc Inst & Hosp, Dept Bone & Soft Tissue Tumors, Tianjin 300060, Peoples R China
[4] Tianjin Med Univ, Canc Inst & Hosp, Dept Pathol, Tianjin 300060, Peoples R China
[5] Tianjin Med Univ, Canc Inst & Hosp, Dept Epidemiol & Biostat, Tianjin 300060, Peoples R China
[6] Fudan Univ, Shanghai Canc Ctr, Dept Pathol, Shanghai 200032, Peoples R China
[7] Univ Texas MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA
[8] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA
来源：
EUROPEAN JOURNAL OF CANCER | 2014年 / 50卷 / 03期
关键词：
Sarcoma; Mesenchymal to epithelial transition; Epithelial differentiation; E-cadherin; Transcriptional factors; Micro RNA; Targeted therapy; SQUAMOUS-CELL CARCINOMA; SOFT-TISSUE SARCOMAS; REGULATES E-CADHERIN; SYNOVIAL SARCOMA; GASTRIC-CANCER; BREAST-CANCER; EXPRESSION; OSTEOSARCOMA; PATHWAY; TUMOR;
D O I：
10.1016/j.ejca.2013.11.006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mesenchymal to epithelial transition ( MET) in carcinomas has been proposed to promote the growth of epithelial tumour cells at distant sites during metastasis. MET has also been suggested as an important biological and clinical process in mesenchymal tumors, sarcomas. Here we review studies on MET in sarcomas, including molecular markers, signalling mechanisms, regulation by micro RNAs and therapeutic implications. Accumulating evidences suggest that deeper investigation and understanding of MET in sarcomas would shed light on the pathogenesis of sarcomas and might lead to identification of potential clinical biomarkers for prognosis and targets for sarcoma therapeutics. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：593 / 601
页数：9
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