Challenges in vaccination of neonates, infants and young children

被引：42
作者：
Pichichero, Michael E. [1 ]
机构：
[1] Rochester Gen Hosp, Res Inst, New York, NY 14621 USA
来源：
VACCINE | 2014年 / 32卷 / 31期
关键词：
Vaccination; Neonate; Infants; Children; B cells; T cells; Antigen presenting cells; Dendritic cells; immunologic memory; pediatric vaccines; Streptococcus pneumoniae; Haemophilus influenzae; B-cell receptor; MHC II; CD4; T-cells; cytokines; T-cell receptor; Toll-like receptor; ACUTE OTITIS-MEDIA; CD4(+) T-CELLS; YELLOW-FEVER VACCINE; TOLL-LIKE RECEPTORS; IMMUNE-RESPONSES; ANTIBODY-RESPONSE; INNATE IMMUNITY; STREPTOCOCCUS-PNEUMONIAE; TRANSCRIPTOME SIGNATURE; HAEMOPHILUS-INFLUENZAE;
D O I：
10.1016/j.vaccine.2014.05.008
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
All neonates, infants and young children receive multiple priming doses and booster vaccinations in the 1st and 2nd year of life to prevent infections by viral and bacterial pathogens. Despite high vaccine compliance, outbreaks of vaccine-preventable infections are occurring worldwide. These data strongly argue for an improved understanding of the immune responses of neonates, infants and young children to vaccine antigens and further study of the exploitable mechanisms to achieve more robust and prolonged immunity with fewer primary and booster vaccinations in the pediatric population. This review will focus on our recent work involving infant and young child immunity following routine recommended vaccinations. The discussion will address vaccine responses with respect to four areas: (1) systemic antibody responses, (2) memory B-cell generation, (3) CD4 T-cell responses, and (4) APC function. (C) 2014 Elsevier Ltd. All rights reserved.
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收藏
页码：3886 / 3894
页数：9
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