Efficacy and Safety of Pyronaridine-Artesunate plus Single-Dose Primaquine for the Treatment of Malaria in Western Cambodia

被引：16

作者：

Leang, Rithea ^{[1
]}

Khim, Nimol ^{[2
]}

Chea, Huch ^{[1
]}

Huy, Rekol ^{[1
]}

Mairet-Khedim, Melissa ^{[2
]}

Bouth, Denis Mey ^{[3
]}

Bustos, Maria Dorina ^{[4
]}

Ringwald, Pascal ^{[5
]}

Witkowski, Benoit ^{[2
]}

机构：

[1] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia

[2] Inst Pasteur Cambodia, Phnom Penh, Cambodia

[3] WHO, Phnom Penh, Cambodia

[4] WHO, Bangkok, Thailand

[5] WHO, Geneva, Switzerland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 10期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

Cambodia; Plasmodium falciparum; Plasmodium vivax; antimalarial agents; artemisinin; drug resistance; malaria; pyronaridine-artesunate; PLASMODIUM-FALCIPARUM MALARIA; ARTEMISININ; PIPERAQUINE; RESISTANCE;

D O I：

10.1128/AAC.01273-19

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This single-arm trial (n = 104) in western Cambodia showed high efficacy for 3-day treatment with pyronaridine-artesunate plus single-dose primaquine in Plasmodium falciparum malaria. Day 42 PCR-adjusted adequate clinical and parasitological response (ACPR) was 98.3% (58/59) (95% confidence interval [CI], 90.9 to 100.0) in Trapeng Chau in Kampong Speu and 100% (41/41) (95% CI, 91.4 to 100) in Veal Veng in Pursat; 80.6% (83/103) of the patients had P. falciparum with drug resistance molecular markers. For Plasmodium vivax malaria, pyronaridine-artesunate day 28 ACPR was 98.3% (59/60) (95% CI, 91.1 to 100) and 100% (60/60) (95% CI, 94.0 to 100), respectively.

引用

页数：5

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