SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden

被引：211

作者：

Rudberg, Ann-Sofie ^{[1
,2
]}

Havervall, Sebastian ^{[3
]}

Manberg, Anna ^{[4
]}

Jernbom Falk, August ^{[4
]}

Aguilera, Katherina ^{[3
]}

Ng, Henry ^{[5
]}

Gabrielsson, Lena ^{[3
]}

Salomonsson, Ann-Christin ^{[3
]}

Hanke, Leo ^{[6
]}

Murrell, Ben ^{[6
]}

McInerney, Gerald ^{[6
]}

Olofsson, Jennie ^{[4
]}

Andersson, Eni ^{[4
]}

Hellstrom, Cecilia ^{[4
]}

Bayati, Shaghayegh ^{[4
]}

Bergstrom, Sofia ^{[4
]}

Pin, Elisa ^{[4
]}

Sjoberg, Ronald ^{[4
]}

Tegel, Hanna ^{[7
]}

Hedhammar, My ^{[7
]}

Phillipson, Mia ^{[5
]}

Nilsson, Peter ^{[4
]}

Hober, Sophia ^{[7
]}

Thalin, Charlotte ^{[3
]}

机构：

[1] Danderyd Hosp, Dept Neurol, Stockholm, Sweden

[2] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[3] Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Div Internal Med, Stockholm, Sweden

[4] KTH Royal Inst Technol, SciLifeLab, Dept Prot Sci, Div Affin Prote, Stockholm, Sweden

[5] Uppsala Univ, SciLifeLab, Dept Med Cell Biol, Uppsala, Sweden

[6] Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden

[7] KTH Royal Inst Technol, Dept Prot Sci, Div Prot Technol, Stockholm, Sweden

来源：

NATURE COMMUNICATIONS | 2020年 / 11卷 / 01期

基金：

瑞典研究理事会;

关键词：

ACUTE RESPIRATORY SYNDROME; SYNDROME SARS;

D O I：

10.1038/s41467-020-18848-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

SARS-CoV-2 may pose an occupational health risk to healthcare workers. Here, we report the seroprevalence of SARS-CoV-2 antibodies, self-reported symptoms and occupational exposure to SARS-CoV-2 among healthcare workers at a large acute care hospital in Sweden. The seroprevalence of IgG antibodies against SARS-CoV-2 was 19.1% among the 2149 healthcare workers recruited between April 14th and May 8th 2020, which was higher than the reported regional seroprevalence during the same time period. Symptoms associated with seroprevalence were anosmia (odds ratio (OR) 28.4, 95% CI 20.6-39.5) and ageusia (OR 19.2, 95% CI 14.3-26.1). Seroprevalence was also associated with patient contact (OR 2.9, 95% CI 1.9-4.5) and covid-19 patient contact (OR 3.3, 95% CI 2.2-5.3). These findings imply an occupational risk for SARS-CoV-2 infection among healthcare workers. Continued measures are warranted to assure healthcare workers safety and reduce transmission from healthcare workers to patients and to the community. Healthcare workers may be at higher risk of SARS-CoV-2 infection than the general population. Here, the authors report 19% seroprevalence of SARS-CoV-2 antibodies among 2,149 employees in a Swedish hospital. Seroprevalence was associated with patient contact and higher than the seroprevalence in the community in same time period.

引用

页数：8

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