A Pediatric Infectious Diseases Perspective of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) and Novel Coronavirus Disease 2019 (COVID-19) in Children

被引：20

作者：

Shane, Andi L. ^{[1
]}

Sato, Alice, I ^{[2
]}

Kao, Carol ^{[1
]}

Adler-Shohet, Felice C. ^{[3
]}

Vora, Surabhi B. ^{[4
,5
]}

Auletta, Jeffery J. ^{[6
,7
,8
]}

Nachman, Sharon ^{[9
]}

Raabe, Vanessa N. ^{[10
,11
]}

Inagaki, Kengo ^{[12
]}

Akinboyo, Ibukunoluwa C. ^{[13
]}

Woods, Charles ^{[14
]}

Alsulami, Abdulsalam O. ^{[15
]}

Kainth, Mundeep K. ^{[16
]}

Santos, Roberto Parulan ^{[17
]}

Espinosa, Claudia M. ^{[18
]}

Burns, Julianne E. ^{[19
]}

Cunningham, Coleen K. ^{[13
]}

Dominguez, Samuel R. ^{[20
,21
]}

Martinez, Beatriz Larru ^{[22
]}

Zhu, Frank ^{[23
]}

Crews, Jonathan ^{[24
]}

Kitano, Taito ^{[25
]}

Saiman, Lisa ^{[26
]}

Kotloff, Karen ^{[27
]}

机构：

[1] Emory Univ, Childrens Healthcare Atlanta, Sch Med, Div Pediat Infect Dis,Dept Pediat, Atlanta, GA USA

[2] Univ Nebraska Med Ctr, Childrens Hosp & Med Ctr, Div Pediat Infect Dis, Omaha, NE USA

[3] Childrens Hosp Orange Cty, Dept Pediat, Div Pediat Infect Dis, Orange, CA 92668 USA

[4] Univ Washington, Dept Pediat, Seattle, WA 98195 USA

[5] Seattle Childrens Hosp, Seattle, WA USA

[6] Nationwide Childrens Hosp, Dept Pediat, Div Pediat Hematol, Columbus, OH USA

[7] Nationwide Childrens Hosp, Dept Pediat, Div Oncol, Columbus, OH USA

[8] Nationwide Childrens Hosp, Dept Pediat, Div Bone Marrow Transplant & Infect Dis, Columbus, OH USA

[9] Stony Brook Childrens, Dept Pediat, Stony Brook, NY USA

[10] NYU, Langone Grossman Sch Med, Dept Med, Div Infect Dis, 550 1St Ave, New York, NY 10016 USA

[11] NYU, Langone Grossman Sch Med, Dept Pediat, Div Infect Dis, New York, NY 10016 USA

[12] Univ Mississippi, Med Ctr, Dept Pediat, Div Pediat Infect Dis, Jackson, MS 39216 USA

[13] Duke Univ, Sch Med, Dept Pediat, Div Pediat Infect Dis, Durham, NC 27706 USA

[14] Univ Tennessee, Coll Med Chattanooga, Dept Pediat, Chattanooga, TN USA

[15] Univ Alabama Birmingham, Dept Pediat, Div Pediat Infect Dis, Birmingham, AL USA

[16] Northwell Hlth, Cohen Childrens Med Ctr, Div Pediat Infect Dis, Dept Pediat, New Hyde Pk, NY USA

[17] Univ Mississippi, Univ Hosp, Med Ctr, Div Pediat Infect Dis,Dept Pediat, Jackson, MS 39216 USA

[18] Univ S Florida, Morsani Coll Med, Div Pediat Infect Dis, Tampa, FL 33620 USA

[19] Univ Penn, Childrens Hosp Philadelphia, Div Hosp Med, Philadelphia, PA 19104 USA

[20] Univ Colorado, Dept Pediat, Sect Infect Dis, Aurora, CO USA

[21] Childrens Hosp Colorado, Aurora, CO USA

[22] Alder Hey Childrens Hosp, Div Paediat Infect Dis & Immunol, Liverpool, Merseyside, England

[23] Med Coll Wisconsin, Dept Pediat, Div Pediat Infect Dis, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA

[24] Baylor Coll Med, Childrens Hosp San Antonio, Div Pediat Infect Dis, San Antonio, TX USA

[25] Univ Toronto, Hosp Sick Children, Dept Pediat, Div Infect Dis, Toronto, ON, Canada

[26] Columbia Univ, New York Presbyterian Morgan Stanley Childrens Ho, Med Ctr, Div Pediat Infect Dis,Dept Pediat, New York, NY 10027 USA

[27] Univ Maryland, Sch Med, Dept Pediat, Div Pediat Infect Dis & Trop Med, Baltimore, MD 21201 USA

来源：

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY | 2020年 / 9卷 / 05期

关键词：

children; COVID-19; pediatrics; novel coronavirus; SARS-CoV-2; UNITED-STATES; REPLICATION; CHLOROQUINE; INHIBITION; REMDESIVIR;

D O I：

10.1093/jpids/piaa099

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Understanding the role that children play in the clinical burden and propagation of severe acute respiratory syndrome coronavirus 2, responsible for coronavirus disease 2019 (COVID-19) infections, is emerging. While the severe manifestations and acute clinical burden of COVID-19 have largely spared children compared with adults, understanding the epidemiology, clinical presentation, diagnostics, management, and prevention opportunities and the social and behavioral impacts on child health is vital. Foremost is clarifying the contribution of asymptomatic and mild infections to transmission within the household and community and the clinical and epidemiologic significance of uncommon severe post-infectious complications. Here, we summarize the current knowledge, identify resources, and outline research opportunities. Pediatric infectious diseases clinicians have a unique opportunity to advocate for the inclusion of children in epidemiological, clinical, treatment, and prevention studies to optimize their care as well as to represent children in the development of guidance and policy during pandemic response.

引用

页码：596 / 608

页数：13

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