A prospective open-label study to evaluate the effects of the oral contraceptive Harmonet® (gestodene75/EE20) on body fat

被引:22
作者
de Melo, NR
Aldrighi, JM
Faggion, D
Reyes, VROY
Souza, JB
Fernandes, CE
Larson, E
机构
[1] Inst Hlth & Well Being Women, BR-04062003 Sao Paulo, SP, Brazil
[2] Univ Sao Paulo, Sch Publ Hlth, Sao Paulo, Brazil
[3] DFJ Clin Med, Sao Paulo, Brazil
[4] Ctr Med Itaquera, Sao Paulo, Brazil
[5] Clin Dr Jose Bento Souza, Sao Paulo, Brazil
[6] CLINCEF, Clin Ginecol & Obstet, Sao Paulo, Brazil
[7] Ctr Paulista Hepatol, Sao Paulo, Brazil
关键词
low-dose oral contraceptive; ethinylestradiol; gestodene; body composition; bioelectrical impedance;
D O I
10.1016/j.contraception.2003.10.016
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
This open-label study evaluated the effects on body fat of the use of a low-dose oral contraceptive (gestodene75/EE20) in a group of 61 women (OC-U group) as compared to a nonuser group (OC-N group) of 51 women who did not receive an oral contraceptive. Weight, body mass index (BMI), waist-over-hip ratio and body composition data, obtained by bioelectrical impedance [percentages of body fat (%FAT), water (%TBW) and lean mass (%FFM)], were assessed before and after six treatment cycles. Baseline OC-U group weight, BMI, %FAT, %TBW and %FFM did not differ from the OC-N group, either at baseline or at the end of the study, and did not significantly change within each group during the study. Also, there was no modification of fat distribution in either group. Among women in the OC-U group, there was a slight increase in total cholesterol levels and a trend towards higher triglycerides levels. No changes were detected in blood pressure. In conclusion, this low-dose oral contraceptive did not affect weight or body composition. Thus, our data suggest that gestodene75/EE20 represents an appropriate OC choice and may enhance compliance of women who mistakenly believe that the use of oral contraceptives always leads to weight gain. (C) 2004 Elsevier Inc. All rights reserved.
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页码:65 / 71
页数:7
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