Treatment planning and dose analysis for interstitial photodynamic therapy of prostate cancer

被引:76
作者
Davidson, Sean R. H. [1 ]
Weersink, Robert A. [2 ]
Haider, Masoom A. [3 ]
Gertner, Mark R. [1 ,4 ]
Bogaards, Arjen [1 ]
Giewercer, David [2 ]
Scherz, Avigdor [5 ]
Sherar, Michael D. [1 ,6 ]
Elhilali, Mostafa [7 ]
Chin, Joseph L. [8 ]
Trachtenberg, John [9 ]
Wilson, Brian C. [1 ]
机构
[1] Univ Hlth Network, Ontario Canc Inst, Div Biophys & Bioimaging, Toronto, ON M5G 2M9, Canada
[2] Univ Hlth Network, Ontario Canc Inst, Lab Appl Biophys, Toronto, ON M5G 2M9, Canada
[3] Univ Hlth Network, Joint Dept Med Imaging, Toronto, ON M5G 2M9, Canada
[4] Ryerson Univ, Dept Phys, Toronto, ON M5B 2K3, Canada
[5] Weizmann Inst Sci, Dept Plant Sci, IL-76100 Rehovot, Israel
[6] Canc Care Ontario, Toronto, ON M5G 2C1, Canada
[7] McGill Univ, Dept Surg, Montreal, PQ H3G 1Y6, Canada
[8] Univ Western Ontario, Dept Oncol, London, ON N6A 5W9, Canada
[9] Univ Hlth Network, Dept Urol, Toronto, ON M5G 2M9, Canada
基金
美国国家卫生研究院;
关键词
NORMAL CANINE PROSTATE; PD-BACTERIOPHEOPHORBIDE TOOKAD; LIGHT DOSIMETRY; RADIOTHERAPY; DELIVERY; PHOTOSENSITIZER; OPTIMIZATION; CARCINOMA; MODEL; WST09;
D O I
10.1088/0031-9155/54/8/003
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
With the development of new photosensitizers that are activated by light at longer wavelengths, interstitial photodynamic therapy (PDT) is emerging as a feasible alternative for the treatment of larger volumes of tissue. Described here is the application of PDT treatment planning software developed by our group to ensure complete coverage of larger, geometrically complex target volumes such as the prostate. In a phase II clinical trial of TOOKAD vascular targeted photodynamic therapy (VTP) for prostate cancer in patients who failed prior radiotherapy, the software was used to generate patient-specific treatment prescriptions for the number of treatment fibres, their lengths, their positions and the energy each delivered. The core of the software is a finite element solution to the light diffusion equation. Validation against in vivo light measurements indicated that the software could predict the location of an iso-fluence contour to within approximately +/-2 mm. The same software was used to reconstruct the treatments that were actually delivered, thereby providing an analysis of the threshold light dose required for TOOKAD-VTP of the post-irradiated prostate. The threshold light dose for VTP-induced prostate damage, as measured one week post-treatment using contrast-enhanced MRI, was found to be highly heterogeneous, both within and between patients. The minimum light dose received by 90% of the prostate, D-90, was determined from each patient's dose-volume histogram and compared to six-month sextant biopsy results. No patient with a D-90 less than 23 J cm(-2) had complete biopsy response, while 8/13 (62%) of patients with a D-90 greater than 23 J cm(-2) had negative biopsies at six months. The doses received by the urethra and the rectal wall were also investigated.
引用
收藏
页码:2293 / 2313
页数:21
相关论文
共 49 条
  • [1] Is extended 11-core biopsy valuable in benign prostatic hyperplasia patients with intermediate serum prostate-specific antigen (4.1-10 ng/ml) and prior negative sextant biopsy?
    Abdel-khalek, M
    El-Baz, M
    Ibrahiem, EH
    [J]. SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, 2004, 38 (04): : 315 - 320
  • [2] Optimized interstitial PDT prostate treatment planning with the Cimmino feasibility algorithm
    Altschuler, MD
    Zhu, TC
    Li, J
    Hahn, SM
    [J]. MEDICAL PHYSICS, 2005, 32 (12) : 3524 - 3536
  • [3] OPTICAL DOSIMETRY FOR INTERSTITIAL PHOTODYNAMIC THERAPY
    ARNFIELD, MR
    TULIP, J
    CHETNER, M
    MCPHEE, MS
    [J]. MEDICAL PHYSICS, 1989, 16 (04) : 602 - 608
  • [4] Monte Carlo modelling of angular radiance in tissue phantoms and human prostate: PDT light dosimetry
    Barajas, O
    Ballangrud, AM
    Miller, GG
    Moore, RB
    Tulip, J
    [J]. PHYSICS IN MEDICINE AND BIOLOGY, 1997, 42 (09) : 1675 - 1687
  • [5] BLENNERHASSETT JB, 1966, CANCER-AM CANCER SOC, V19, P980, DOI 10.1002/1097-0142(196607)19:7<980::AID-CNCR2820190711>3.0.CO
  • [6] 2-0
  • [7] OPTIMIZATION OF PHOTODYNAMIC THERAPY LIGHT DOSE DISTRIBUTION AND TREATMENT VOLUME BY MULTIFIBER INSERTIONS
    BOLIN, FP
    PREUSS, LE
    TAYLOR, RC
    [J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1987, 46 (05) : 609 - 617
  • [8] BYAR DP, 1972, CANCER-AM CANCER SOC, V30, P5, DOI 10.1002/1097-0142(197207)30:1<5::AID-CNCR2820300103>3.0.CO
  • [9] 2-S
  • [10] A versatile nanocrystal-based multi-sensory fiber-optic probe for dosimetry in PDT and thermal treatment
    Chang, Tung-Wah Frederick
    Boesen, Mari
    Weersink, Robert
    Charron, Luc
    Sargent, Edward H.
    Lilge, Lothar
    [J]. OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY XVI, 2007, 6427