Exchange of genetic material: a new paradigm in bone cell communications

被引：6

作者：

Yin, Pengbin ^{[1
]}

Li, Yi ^{[1
]}

Lv, Houchen ^{[1
]}

Deng, Yuan ^{[1
]}

Meng, Yutong ^{[1
]}

Zhang, Licheng ^{[1
]}

Tang, Peifu ^{[1
]}

机构：

[1] Chinese Peoples Liberat Army Gen Hosp, Dept Orthopaed, 28 Fuxing Rd, Beijing 100853, Peoples R China

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2018年 / 75卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Genetic material; Extracellular vesicles; Gap junction; RNA binding protein; Bone cells; Cell-to-cell communication; EXTRACELLULAR VESICLES; CIRCULATING MICRORNAS; STEM-CELL; POSTMENOPAUSAL WOMEN; GAP-JUNCTIONS; TO-CELL; RNA; EXOSOMES; DIFFERENTIATION; SERUM;

D O I：

10.1007/s00018-018-2782-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An emerging concept in intercellular communication in mammals is that communication can be mediated by exchange of genetic material, mainly in the form of RNAs. In this review, we discuss recent studies that describe the trafficking of genetic material with a focus on bone cell communication. Three major carriers are discussed: gap junctions, protein-binding complexes, and genetic material exchange mediated by extracellular vesicles. While protein-level exchange has been well documented, no review has summarized the novel paradigm of cell-to-cell communication by genetic information exchange in bone tissues or its biological relevance in terms of bone homeostasis and bone-related diseases. The purpose of this review is to promote further understanding of this novel discovery regarding bone cell communication and provide references for further investigations.

引用

页码：1989 / 1998

页数：10

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