Preclinical development of T cell receptor gene therapy

被引：41

作者：

Bendle, Gavin M. ^{[1
]}

Haanen, John B. A. G. ^{[2
]}

Schumacher, Ton N. M. ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Immunol, NL-1066 CX Amsterdam, Netherlands

[2] Netherlands Canc Inst, Div Med Oncol, NL-1066 CX Amsterdam, Netherlands

来源：

CURRENT OPINION IN IMMUNOLOGY | 2009年 / 21卷 / 02期

关键词：

ENHANCED ANTITUMOR-ACTIVITY; TCR-ALPHA-BETA; IN-VIVO; CANCER REGRESSION; ANTILEUKEMIC REACTIVITY; TUMOR PROTECTION; SINGLE-CHAIN; LYMPHOCYTES; IMMUNOTHERAPY; ANTIGEN;

D O I：

10.1016/j.coi.2009.02.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The adoptive transfer of TCR gene-modified T cells has been developed with the aim to induce immune reactivity toward defined tumor-associated antigens to which the endogenous T cell repertoire is non-responsive. Here we discuss in which areas preclinical studies in mouse models can or cannot be expected to be of value to guide clinical trial design, and how the available data from preclinical studies should influence forthcoming clinical trials.

引用

页码：209 / 214

页数：6

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