An open-label study of controlled-release melatonin in treatment of sleep disorders in children with autism

被引：126
|
作者：
Giannotti, F.
Cortesi, F.
Cerquiglini, A.
Bernabei, P.
机构：
[1] Univ Roma La Sapienza, Dept Dev Neurol & Psychiat, Ctr Pediat Sleep Disorders, I-00185 Rome, Italy
[2] Univ Roma La Sapienza, Dept Dev Neurol & Psychiat, PDD Clin, I-00185 Rome, Italy
来源：
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2006年 / 36卷 / 06期
关键词：
sleep disorders; autism; melatonin treatment; long-term study;
D O I：
10.1007/s10803-006-0116-z
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Long-term effectiveness of controlled-release melatonin in 25 children, aged 2.6-9.6 years with autism without other coexistent pathologies was evaluated openly. Sleep patterns were studied using Children's Sleep Habits Questionnaire (CSHQ) and sleep diaries at baseline, after 1-3-6 months melatonin treatment and 1 month after discontinuation. Sleep diary and CSHQ showed a more problematic sleep in autistic children compared with controls. During treatment sleep patterns of all children improved. After discontinuation 16 children returned to pre-treatment score, readministration of melatonin was again effective. Treatment gains were maintained at 12 and 24-month follow-ups. No adverse side effects were reported. In conclusion, controlled-release melatonin may provide an effective and well-tolerated treatment for autistic children with chronic sleep disorders.
引用
收藏
页码：741 / 752
页数：12
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