A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles

被引：44

作者：

Banerjee, Arnab ^{[1
]}

Alves, Vitor ^{[2
]}

Rondao, Tiago ^{[3
]}

Sereno, Jose ^{[2
]}

Neves, Angela ^{[2
]}

Lino, Miguel ^{[1
,3
]}

Ribeiro, Andreia ^{[1
]}

Abrunhosa, Antero J. ^{[2
]}

Ferreira, Lino S. ^{[1
,3
]}

机构：

[1] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, P-3004517 Coimbra, Portugal

[2] Univ Coimbra, ICNAS CIBIT Inst Nucl Sci Appl Hlth, Coimbra Inst Biomed Imaging & Translat Res, P-3000548 Coimbra, Portugal

[3] Univ Coimbra, Fac Med, P-3004504 Coimbra, Portugal

来源：

NANOSCALE | 2019年 / 11卷 / 28期

基金：

欧盟地平线“2020”;

关键词：

FUNCTIONAL RECOVERY; ENDOTHELIAL-CELLS; STEM-CELLS; EXOSOMES; COPPER; SYSTEMS; BIODISTRIBUTION; ANGIOGENESIS; BIOGENESIS; STABILITY;

D O I：

10.1039/c9nr02512j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we report a two-step surface modification methodology to radiolabel small extracellular vesicles (SEVs) with (CuCl2)-Cu-64 for PET/MRI imaging. The modification did not change or damage the morphology, surface receptor proteins and internal RNA content. Radiolabeled SEVs could be detected in organs with low accumulation such as the brain (0.4-0.5% ID g(-1)) and their brain location determined by MRI.

引用

页码：13243 / 13248

页数：6

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