Supramolecular Vesicles for Stimulus-Responsive DrugDelivery

被引：70

作者：

Xing, Pengyao ^{[1
]}

Zhao, Yanli ^{[1
,2
]}

机构：

[1] Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, 21 Nanyang Link, Singapore 637371, Singapore

[2] Nanyang Technol Univ, Sch Mat Sci & Engn, 50 Nanyang Ave, Singapore 639798, Singapore

来源：

SMALL METHODS | 2018年 / 2卷 / 04期

基金：

新加坡国家研究基金会;

关键词：

cancer therapy; drug release; stimulus responsive; supramolecular self-assembly; vesicles; SELF-ASSEMBLED VESICLES; DRUG-DELIVERY SYSTEM; MOLECULAR RECOGNITION; MULTIFUNCTIONAL NANOPARTICLES; TARGETED CHEMOTHERAPY; WATER; RELEASE; AMPHIPHILE; COMPLEX; ACID;

D O I：

10.1002/smtd.201700364

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Developing smart controlled-release systems for cancer therapy is highly desired in biomedicine. In order to improve therapeutic efficacy and lower undesired side effects, the construction of stimulus-responsive nanocarriers is a favorable solution. Emerging supramolecular self-assemblies possessing intrinsic dynamic and adaptive features present promising capabilities for the fabrication of stimulus-responsive drug-release systems. Dynamic supramolecular vesicles have attracted considerable attention as therapeutic carriers ascribed to their advantages of high-cargo-loading capacity/feasibility, excellent biocompatibility, and facile functionalization. Here, a summary and discussion of recent significant development of vesicles constructed by supramolecular self-assembly for stimulus-responsive drug delivery and therapeutics is given. Through presenting some representative studies, strategies regarding the design, synthesis, characterization, and biomedical applications of supramolecular vesicle carriers are highlighted according to various stimulus triggers. The aim is to provide a quick research update in this rapidly developing field.

引用

页数：16

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