Copper(II)-Mediated O-Arylation of Protected Serines and Threonines

被引：30
|
作者：
El Khatib, Mirna [1 ]
Molander, Gary A. [1 ]
机构：
[1] Univ Penn, Dept Chem, Roy & Diana Vagelos Labs, Philadelphia, PA 19104 USA
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 18期
关键词：
COPPER-CATALYZED SYNTHESIS; CARBON BOND FORMATION; PHENYLBORONIC ACIDS; ARYLBORONIC ACIDS; ROOM-TEMPERATURE; DIARYL ETHERS; EFFICIENT SYNTHESIS; ALIPHATIC-ALCOHOLS; VINYLBORONIC ACID; PEPTIDE-SYNTHESIS;
D O I：
10.1021/ol5024689
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An effective protocol toward the O-arylation of beta-hydroxy-alpha-amino acid substrates serine and threonine has been developed via Chan-Lam cross-coupling. This Cu(II)-catalyzed transformation involves benign open-flask conditions that are well-tolerated with a variety of protected (Boc., Cbz-, Tr-, and Fmoc-) serine and threonine derivatives and various potassium organotrifluoroborates and boronic acids.
引用
收藏
页码：4944 / 4947
页数：4
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