Cardioprotective Utility of Urocortin in Myocardial Ischemia-Reperfusion Injury: Where do We Stand?

被引：4

作者：

Basman, Craig ^{[1
]}

Agrawal, Pratik ^{[2
,3
]}

Knight, Richard ^{[2
,3
]}

Saravolatz, Louis ^{[2
,3
]}

Mcree, Chad ^{[4
]}

Chen-Scarabelli, Carol ^{[5
]}

Narula, Jagat ^{[6
]}

Scarabelli, Tiziano ^{[4
,5
]}

机构：

[1] North Shore LIJ Hlth Syst, Lenox Hill Hosp, New York, NY USA

[2] Wayne State Univ, Sch Med, St John Hosp, Detroit, MI USA

[3] Wayne State Univ, Sch Med, Med Ctr, Detroit, MI USA

[4] Virginia Commonwealth Univ, Med Ctr, Dept Cardiol, Tuscaloosa, AL USA

[5] Univ Alabama Birmingham, Birmingham Vet Affairs Med Ctr, Birmingham, AL USA

[6] Icahn Sch Med Mt Sinai, Mt Sinai Med Ctr, New York, NY 10029 USA

来源：

CURRENT MOLECULAR PHARMACOLOGY | 2018年 / 11卷 / 01期

关键词：

Urocortin; ischemia-reperfusion; cytoprotection; corticotropins; cell death; cellular metabolism; myocardial; CORTICOTROPIN-RELEASING-FACTOR; MITOCHONDRIAL PERMEABILITY TRANSITION; SENSITIVE POTASSIUM CHANNELS; CARDIAC MYOCYTES; ISCHEMIA/REPERFUSION INJURY; INFARCT EXPANSION; GENE-EXPRESSION; CELL-SURVIVAL; HEART; ACTIVATION;

D O I：

10.2174/1874467210666170223101422

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: There has been a constant pursuit for development of newer therapies which can contribute to the relatively nascent field of cardioprotection in the setting of myocardial ischemia-reperfusion injury. One novel cardioprotective agent among others, that has shown promising results in the limited number of research studies undertaken till now, is Urocortin. Urocortins are peptides belonging to the Corticotropin-Releasing Hormone family. Results: Acting through a variety of downstream mechanisms, urocortin has been shown to alter cellular metabolism and modulate the mechanism of cell death occurring as a result of ischemia-reperfusion injury. New evidence continues to accumulate in support of urocortin's beneficial role in cytoprotection. Conclusion: We present here an updated review largely focused on the various mechanisms through which urocortin alters cellular metabolism, and discuss the clinical potential of urocortin's cardioprotective ability in myocardial ischemia-reperfusion injury.

引用

页码：32 / 38

页数：7

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