High-Resolution 3D Proton MRI of Hyperpolarized Gas Enabled by Parahydrogen and Rh/TiO2 Heterogeneous Catalyst

被引：71

作者：

Kovtunov, Kirill V. ^{[1
,2
]}

Barskiy, Danila A. ^{[1
,2
]}

Coffey, Aaron M. ^{[3
,4
]}

Truong, Milton L. ^{[3
,4
]}

Salnikov, Oleg G. ^{[1
,2
]}

Khudorozhkov, Alexander K. ^{[5
]}

Inozemtseva, Elizaveta A. ^{[5
]}

Prosvirin, Igor P. ^{[5
]}

Bukhtiyarov, Valery I. ^{[5
]}

Waddell, Kevin W. ^{[3
,4
]}

Chekmenev, Eduard Y. ^{[3
,4
]}

Koptyug, Igor V. ^{[1
,2
]}

机构：

[1] SB RAS, Lab Magnet Resonance Microimaging, Int Tomog Ctr, 3A Inst Skaya St, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, Novosibirsk 630090, Russia

[3] Vanderbilt Univ, Med Ctr, Dept Radiol, Inst Imaging Sci,Dept Biomed Engn,Dept Phys & Ast, Nashville, TN 37232 USA

[4] Vanderbilt Univ, Dept Biochem, Nashville, TN 37232 USA

[5] Boreskov Inst Catalysis SB RAS, Novosibirsk 630090, Russia

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 37期

关键词：

heterogeneous catalysis; hyperpolarized gas; magnetic resonance imaging; parahydrogen; supported catalysts; HYDROGEN-INDUCED POLARIZATION; NUCLEAR-POLARIZATION; NMR; FIELD;

D O I：

10.1002/chem.201403604

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Several supported metal catalysts were synthesized, characterized, and tested in heterogeneous hydrogenation of propene with parahydrogen to maximize nuclear spin hyperpolarization of propane gas using parahydrogen induced polarization (PHIP). The Rh/TiO2 catalyst with a metal particle size of 1.6 nm was found to be the most active and effective in the pairwise hydrogen addition and robust, demonstrating reproducible results with multiple hydrogenation experiments and stability for >= 1.5 years. 3D H-1 magnetic resonance imaging (MRI) of 1% hyperpolarized flowing gas with microscale spatial resolution (625 x 625 x 625 mu m(3)) and large imaging matrix (128 x 128 x 32) was demonstrated by using a preclinical 4.7 T scanner and 17.4 s imaging scan time.

引用

页码：11636 / 11639

页数：4

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