Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches

被引：46

作者：

Zhang, Lei ^{[1
]}

Mack, Ryan ^{[1
]}

Breslin, Peter ^{[1
,2
,3
,4
]}

Zhang, Jiwang ^{[1
,5
]}

机构：

[1] Loyola Univ Med Ctr, Inst Oncol, Dept Canc Biol, Cardinal Bernardin Canc Ctr, Maywood, IL 60153 USA

[2] Loyola Univ Med Ctr, Dept Mol Cellular Physiol, Chicago, IL 60660 USA

[3] Loyola Univ Med Ctr, Dept Biol, Chicago, IL 60660 USA

[4] Loyola Univ, Chicago, IL 60660 USA

[5] Loyola Univ Med Ctr, Dept Pathol, Maywood, IL 60153 USA

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2020年 / 13卷 / 01期

关键词：

HSCs; Aging; Replication stress; MESENCHYMAL STROMAL CELLS; SELF-RENEWAL CAPACITY; COMBINED SINGLE-CELL; AGE-RELATED-CHANGES; BONE-MARROW; ENDOTHELIAL-CELLS; PROGENITOR CELLS; CLONAL ANALYSIS; DNA-DAMAGE; IN-VIVO;

D O I：

10.1186/s13045-020-00994-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aging drives the genetic and epigenetic changes that result in a decline in hematopoietic stem cell (HSC) functioning. Such changes lead to aging-related hematopoietic/immune impairments and hematopoietic disorders. Understanding how such changes are initiated and how they progress will help in the development of medications that could improve the quality life for the elderly and to treat and possibly prevent aging-related hematopoietic diseases. Here, we review the most recent advances in research into HSC aging and discuss the role of HSC-intrinsic events, as well as those that relate to the aging bone marrow niche microenvironment in the overall processes of HSC aging. In addition, we discuss the potential mechanisms by which HSC aging is regulated.

引用

页数：22

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