Diversity in the emotional modulation of pain perception: An account of individual variability

BackgroundWhile emotional state has been shown to modulate pain perception, there has been little consideration for the individual variability in this effect, or what factors may contribute to individual-level differences. The objective of this study was to characterize the variability in emotional modulation of pain in a healthy sample. MethodsTwenty-five healthy, adult females participated in a heat pain-rating task. After calibration of the appropriate temperature for each participant, the pain-rating task was combined with viewing of positive, neutral, or negative valence images. Participants rated pain intensity and unpleasantness of the painful stimulus. ResultsThe magnitude of the effect for emotional modulation of pain was markedly variable across individuals. Some participants exhibited greater pain relief from the positive emotional stimuli while others were more susceptible to pain amplification from the negative emotional stimuli. There were also significant correlations between emotional modulation of pain and specific psychological measures (depression and anxiety). ConclusionOverall, inducing a positive emotional state mitigates pain perception, while negative emotional state amplifies it. The magnitudes of these separate pain-modulating effects, however, vary across individuals, and are associated with individual levels of depressive and anxious feelings, even within a non-clinical population. SignificanceThe opposite effects of valence on pain amplification and modulation revealed in this study are novel. This study shows that emotional modulation of pain varies markedly across individuals and is related to psychological factors including depression and anxiety. Examining this link in healthy individuals may inform our understanding of the comorbidity between pain and depression/anxiety.