Development of universal influenza vaccines based on influenza virus M and NP genes

被引：71
作者：
Zheng, M. [1 ]
Luo, J. [1 ]
Chen, Z. [1 ,2 ,3 ]
机构：
[1] Shanghai Inst Biol Prod, Shanghai 200052, Peoples R China
[2] Chinese Acad Sci, Wuhan Inst Virol, State Key Lab Virol, Wuhan 430071, Hubei, Peoples R China
[3] Hunan Normal Univ, Coll Life Sci, Changsha 410081, Hunan, Peoples R China
来源：
INFECTION | 2014年 / 42卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Influenza virus; Universal vaccine; Matrix protein; Nucleoprotein; Broad spectrum; NUCLEOPROTEIN PROTECTS MICE; IMMUNOGLOBULIN-A ANTIBODIES; ANTIGENIC PEPTIDE VACCINE; T-CELL EPITOPE; MATRIX PROTEIN-2; INTRACELLULAR NEUTRALIZATION; RECOMBINANT NUCLEOPROTEIN; MONOCLONAL-ANTIBODY; HIV-1; REPLICATION; LETHAL INFECTION;
D O I：
10.1007/s15010-013-0546-4
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Purpose Vaccination is the safest and most effective measure against influenza virus infections. However, traditional influenza vaccines cannot respond effectively to an unforeseen epidemic or pandemic caused by a virus with antigenic drifts or antigenic shifts. Therefore, developing a universal influenza vaccine (UIV) that induces broad-spectrum and long-term immunity has become a major trend in influenza vaccine research and development. Methods This article reviews the development of UIVs based on these conserved influenza virus proteins. Results and Conclusion The matrix protein (M1, M2) and nucleoprotein (NP) of influenza viruses have highly conserved sequences, and they become the major target antigens of current UIV studies.
引用
收藏
页码：251 / 262
页数：12
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