Phytosynthesis of silver nanoparticles (AgNPs) using miracle fruit plant (Synsepalum dulcificum) for antimicrobial, catalytic, anticoagulant, and thrombolytic applications

被引：61

作者：

Lateef, Agbaje ^{[1
,2
]}

Akande, Monsurat A. ^{[1
]}

Azeez, Musibau A. ^{[2
,3
]}

Ojo, Sunday A. ^{[1
]}

Folarin, Bolaji I. ^{[1
]}

Gueguim-Kana, Evariste B. ^{[4
]}

Beukes, Lorika S. ^{[5
]}

机构：

[1] Ladoke Akintola Univ Technol, Dept Pure & Appl Biol, Lab Ind Microbiol & Nanobiotechnol, PMB 4000, Ogbomosho, Nigeria

[2] Ladoke Akintola Univ Technol, Nanotechnol Res Grp NANO, PMB 4000, Ogbomosho, Nigeria

[3] Ladoke Akintola Univ Technol, Dept Pure & Appl Biol, PMB 4000, Ogbomosho, Nigeria

[4] Univ KwaZulu Natal, Dept Microbiol, Private Bag X01, ZA-3209 Scottsville, Pietermaritzbur, South Africa

[5] Univ KwaZulu Natal, Sch Life Sci, Microscopy & Microanal Unit, Private Bag X01, ZA-3209 Scottsville, Pietermaritzbur, South Africa

来源：

NANOTECHNOLOGY REVIEWS | 2016年 / 5卷 / 06期

关键词：

antimicrobial activity; phytosynthesis; silver nanoparticles; Synsepalum dulcificum; thrombolysis; GOLD NANOPARTICLES; GREEN SYNTHESIS; METHYLENE-BLUE; BARK EXTRACT; LEAF EXTRACT; BIOSYNTHESIS; CANCER; COAGULATION; DEGRADATION; MECHANISMS;

D O I：

10.1515/ntrev-2016-0039

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the present work, we report the phytosynthesis of AgNPs mediated by leaf and seed extracts of Synsepalum dulcificum. The extracts catalyzed the formation of brown colloidal AgNPs, which stabilized in 10 min. The leaf and seed AgNPs yielded surface plasmon resonance at 440 and 438.5 nm, respectively. Prominent peaks at 3408, 2357, 2089, and 1639 cm(-1) were recorded for leaf AgNPs, whereas 3404, 2368, 2081, and 1641 cm(-1) were revealed for seed-mediated AgNPs from Fourier transform infrared data. These showed the involvement of phenolic compounds and proteins in the phytosynthesis. The particles were fairly spherical and crystalline in nature having size of 4-26 nm, with prominence of silver in the colloidal solutions. The particles inhibited the growth of drugresistant strains of Pseudomonas aeruginosa and Klebsiella granulomatis with zone of inhibition of 11-24 mm. Also, the phytosynthesized AgNPs completely inhibited the growth of Aspergillus flavus and Aspergillus niger. In addition, by using 20 mu g/ml of AgNPs, malachite green was degraded by approximately 80% in 24 h. Similarly, the particles displayed blood anticoagulant activities as well as achieved thrombolysis. The AgNPs can be explored for biomedical and catalytic applications. The report is the first on the eco-friendly synthesis of nanoparticles by S. dulcificum.

引用

页码：507 / 520

页数：14

共 62 条

[31] Public health issues in the processing of cassava (Manihot esculenta) for the production of lafun and the application of hazard analysis control measures [J].