Addicted to secrete - novel concepts and targets in cancer therapy

被引：70

作者：

Dejeans, Nicolas ^{[1
,2
]}

Manie, Serge ^{[3
,4
]}

Hetz, Claudio ^{[5
,6
,7
]}

Bard, Frederic ^{[8
,9
]}

Hupp, Ted ^{[10
]}

Agostinis, Patrizia ^{[11
]}

Samali, Afshin ^{[12
]}

Chevet, Eric ^{[1
,2
,3
]}

机构：

[1] INSERM, U1053, F-33000 Bordeaux, France

[2] Univ Bordeaux Segalen, F-33000 Bordeaux, France

[3] Univ Lyon, F-69000 Lyon, France

[4] Canc Res Ctr Lyon, INSERM 1052, UMR CNRS 5286, F-69000 Lyon, France

[5] Univ Chile, Fac Med, ICBM, Bionned Neurosci Inst, Santiago 7, Chile

[6] Neurounion Biomed Fdn, Santiago, Chile

[7] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[8] Natl Univ Singapore, Inst Mol & Cell Biol, Lab Regulat Membrane Traff, Singapore 117548, Singapore

[9] Natl Univ Singapore, Dept Biochem, Singapore 117548, Singapore

[10] Univ Edinburgh, Edinburgh Canc Res Ctr, Signal Transduct Labs p53, Cell Signaling Unit, Edinburgh EH4 2XR, Midlothian, Scotland

[11] Univ Leuven KU Leuven, Dept Cellular & Mol Med, Louvain, Belgium

[12] NUI Galway, Sch Nat Sci, Apoptosis Res Ctr, Galway, Ireland

来源：

TRENDS IN MOLECULAR MEDICINE | 2014年 / 20卷 / 05期

基金：

英国生物技术与生命科学研究理事会;

关键词：

unfolded protein response; secretory pathway; cancer therapy; UNFOLDED PROTEIN RESPONSE; SULFHYDRYL OXIDASE 1; TUMOR-CELLS; CALRETICULIN EXPOSURE; SOMATIC MUTATIONS; O-GLYCOSYLATION; INHIBITOR; RESISTANCE; EXPRESSION; AUTOPHAGY;

D O I：

10.1016/j.molmed.2013.12.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The unfolded protein response (UPR) mediates the adaptation of the secretory pathway (SP) to fluctuations in cellular protein demand or to environmental variations. Recently, drug screenings have confirmed the therapeutic potential of targeting the UPR in cancer models. However, the UPR may not be the only druggable target of the SP. Moreover, recent studies have revealed other contributions of the SP to cancer development. This article does not intend to describe the well-established implication of UPR signaling pathways in cancer cell life and cell decision, but rather aims at defining the concept of 'tumor cell secretory addiction', from molecular, cellular, and therapeutic perspectives. Furthermore, the implication of UPR modulations in this context will be discussed.

引用

页码：242 / 250

页数：9

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