Vitamin D deficiency in solid-organ transplant recipients from a Spanish Mediterranean population

被引:5
作者
Ferrandiz-Pulido, C. [1 ]
Torres, I. B. [2 ]
Juarez-Dobjanschi, C. [1 ]
Zarzoso-Munoz, I. [1 ]
Berastegui, C. [3 ]
Castells, L. [4 ]
Garcia-Patos, V. [1 ]
Moreso, F. [2 ]
机构
[1] Hosp Univ Vall Hebron, Dept Dermatol, Passeig Vall dHebron 119-129, Barcelona 08035, Spain
[2] Hosp Univ Vall Hebron, Dept Nephrol, Barcelona, Spain
[3] Hosp Univ Vall Hebron, Dept Pneumol, Barcelona, Spain
[4] Hosp Univ Vall Hebron, Dept Internal Med Hepatol, Barcelona, Spain
关键词
25-HYDROXYVITAMIN D; CANCER-MORTALITY; RISK; DYSFUNCTION; PROTECTION;
D O I
10.1111/ced.13915
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background Solid-organ transplant recipients (SOTRs) are at risk of developing vitamin D deficiency, mainly caused by reduced sunlight exposure with subsequent low vitamin D synthesis in the skin. Aim To analyse whether SOTRs from a Spanish Mediterranean region were vitamin D-deficient. Methods This was a cross-sectional, descriptive and observational study in a transplantation-specialized Dermatological Unit from a Mediterranean area to determine the calcidiol levels of a cohort of 78 consecutively attending patients not receiving vitamin D supplements. Serum 25(OH)D-3 levels were determined and clinical characteristics were collected. Logistic regression analysis was used to analyse variables associated with dichotomized 25(OH)D-3 levels (<= or > 10 ng/mL). Results The cohort comprised 30 lung, 29 kidney and 19 liver transplant recipients. Mean calcidiol was 18 +/- 9 ng/mL. Deficiency of 25(OH)D-3 was present in 19% of patients, while 68% had insufficient levels and 13% had sufficient levels. Following multivariate logistic regression analysis, the season of blood sampling remained the only predictor of deficient 25(OH)D-3 levels. Conclusion Despite living in a mid-latitude country with sunny weather, our SOTR population was at high risk of developing hypovitaminosis D, especially in autumn/winter. Avoiding sun exposure is important to prevent skin cancer, but careful monitoring of vitamin D status is recommended, with supplementation if hypovitaminosis D is detected.
引用
收藏
页码:E103 / E109
页数:7
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