Role of microRNAs in the regulation of innate immune cells under neuroinflammatory conditions

被引：63

作者：

Cardoso, Ana L. ^{[1
]}

Guedes, Joana R. ^{[1
,2
,3
]}

Pedroso de Lima, Maria C. ^{[1
,4
]}

机构：

[1] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, Coimbra, Portugal

[2] Univ Coimbra, CNC Ctr Neurosci & Cell Biol, Doctoral Programme Expt Biol & Biomed, Coimbra, Portugal

[3] Univ Coimbra, Inst Interdisciplinary Res, Coimbra, Portugal

[4] Univ Coimbra, Fac Sci & Technol, Dept Life Sci, Coimbra, Portugal

来源：

CURRENT OPINION IN PHARMACOLOGY | 2016年 / 26卷

关键词：

BLOOD-BRAIN-BARRIER; ALZHEIMERS-DISEASE; TRANSCRIPTION FACTOR; MICROGLIAL CELLS; EXPRESSION; MIR-155; MACROPHAGES; TISSUE; ALPHA; ACTIVATION;

D O I：

10.1016/j.coph.2015.09.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

MiRNAs are short, evolutionary conserved noncoding RNA molecules with the ability to control the magnitude of inflammation. The immunosuppressive nature of the brain is sustained by miRNA-dependent regulation of microglial cells, which become activated under neuroinflammatory conditions, such as brain injury and neurodegeneration. The pro inflammatory and suppressive role of the most studied neuroimmune miRNAs, miR-155 and miR-146a, has been recently challenged. Although the molecular targets of these miRNAs remain unchanged across brain diseases, different kinetics of miRNA expression and degradation can produce different immune outcomes and change microglia phenotypes. Here, we discuss current knowledge regarding the implications of disruption of miRNA networks in neuroinflammation and in the pathophysiology of acute and chronic CNS diseases.

引用

页码：1 / 9

页数：9

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