Structural and Biological Insights into the Hot-Spot Marine Natural Products Reported from 2012 to 2021

被引：20
作者：
Liu, Mingyu [1 ,2 ]
Zhang, Xingwang [2 ]
Li, Guoqiang [1 ,3 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Shandong, Peoples R China
[2] Shandong Univ, State Key Lab Microbial Technol, Qingdao 266237, Shandong, Peoples R China
[3] Natl Lab Marine Sci & Technol, Lab Marine Drugs & Biol Prod, Qingdao 266235, Shandong, Peoples R China
来源：
CHINESE JOURNAL OF CHEMISTRY | 2022年 / 40卷 / 15期
基金：
中国国家自然科学基金;
关键词：
Natural products; Marine drugs; Biological activity; Drug discovery; Novel structures; FUNGUS STACHYBOTRYS-CHARTARUM; A-C; STRUCTURE ELUCIDATION; DICHLORINATED POLYKETIDE; BROMOPYRROLE ALKALOIDS; ABSOLUTE-CONFIGURATION; SESQUITERPENE QUINONES; ALGICOLOUS STRAIN; INDOLE ALKALOIDS; DRUG DISCOVERY;
D O I：
10.1002/cjoc.202200129
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Comprehensive Summary The vast marine ecosystem contains a sea of natural products, which are potential model molecules for new drug development. With more than one thousand new structures been discovered each year, the past decade has become the golden time for marine natural product discovery, leading to a valuable but extra-large chemical database. Serving as an epitome of the most promising compounds, which take the ultra-new skeletons and/or excellent bioactivities, this review covers 243 hot-spot marine natural products reported from 2012 to 2021, to abstract some important chemical and/or biological inspirations for marine natural product study and marine drug development in the future. In addition, some general rules regarding to the source organism, structure-specialty, organism-structure specificity, and organism-bioactivity relationship of these outstanding compounds will also be presented.
引用
收藏
页码：1867 / 1889
页数：23
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