Comparison of surgery or radiotherapy on complications and quality of life in patients with the stage IB and IIA uterine cervical cancer

被引:57
作者
Hsu, Wei-Chung [2 ]
Chung, Na-Na [2 ]
Chen, Yu-Chia [1 ]
Ting, Lai-Lei [3 ,4 ]
Wang, Po-Ming [2 ]
Hsieh, Pao-Chun [5 ]
Chan, Shu-Ching [6 ]
机构
[1] Natl Dong Hwa Univ, Coll Indigenous Studies, Program Indigenous Social Work, Shoufeng 97401, Hualien, Taiwan
[2] Cheng Ching Gen Hosp, Dept Radiat Oncol, Taichung, Taiwan
[3] Natl Taiwan Univ Hosp, Dept Oncol, Div Radiat Oncol, Taipei, Taiwan
[4] Natl Taiwan Univ, Coll Med, Dept Radiol, Taipei 10764, Taiwan
[5] Cheng Ching Gen Hosp, Dept Obstet & Gynecol, Taichung, Taiwan
[6] Asia Univ, Dept Healthcare Adm, Taichung, Taiwan
关键词
Quality of life; Complication; Radiotherapy; Surgery; Uterine cervical cancer; SPARING RADICAL HYSTERECTOMY; TAIWAN CHINESE VERSION; SEXUAL FUNCTION; EORTC QLQ-C30; VAGINAL CHANGES; CARCINOMA; QLQ-H-AND-N35; VALIDATION; MANAGEMENT; SURVIVORS;
D O I
10.1016/j.ygyno.2009.06.028
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objectives. To compare the long-term complications and quality of life of patients with stage IB and stage IIA uterine cervical carcinoma treated by surgery or radiotherapy. Methods. From August 2003 to May 2004, 202 patients with uterine cervical carcinoma were treated with surgery or radiotherapy at two institutions and were enrolled in this study upon follow-up at least 2 years post treatment. All patients completed the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and complications Questionnaire. Results. Constipation (P<0.001), flushing (p<0.001), dysuria (p<0.001), urinary incontinence (p<0.01), dysparia (p<0.05) and vaginal dryness (p<0.05) were statistically higher in the surgery treated group, while diarrhea (p<0.001), bloody stools (p<0.001) and abdominal pain (p<0.01) were higher in the radiotherapy group. Using factor analysis and introducing personal conditioned variables, pelvic neural dysfunction was significantly higher in surgery group and intestinal dysfunction was higher in radiotherapy group. There was no difference in sexual dysfunction between these two modalities. Comparison of EORTC QLQ-C30 showed that the majority of issues had minimal differences between these two treatment modalities, except social functioning (p<0.05; higher in radiotherapy group), constipation (p<0.001; higher in surgery group) and diarrhea (p<0.01; higher in radiotherapy group). Conclusions. In early stage uterine cervical cancer patients, surgery or radiotherapy resulted in different complications, whereas long-term quality of life showed few differences between these two different modalities. These data were helpful for physicians in regards to the changes of patients, and moreover, for rehabilitation and supportive care of the patients after treatment. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码:41 / 45
页数:5
相关论文
共 30 条
[1]   THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER QLQ-C30 - A QUALITY-OF-LIFE INSTRUMENT FOR USE IN INTERNATIONAL CLINICAL-TRIALS IN ONCOLOGY [J].
AARONSON, NK ;
AHMEDZAI, S ;
BERGMAN, B ;
BULLINGER, M ;
CULL, A ;
DUEZ, NJ ;
FILIBERTI, A ;
FLECHTNER, H ;
FLEISHMAN, SB ;
DEHAES, JCJM ;
KAASA, S ;
KLEE, M ;
OSOBA, D ;
RAZAVI, D ;
ROFE, PB ;
SCHRAUB, S ;
SNEEUW, K ;
SULLIVAN, M ;
TAKEDA, F .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (05) :365-376
[2]   Vaginal changes and sexuality in women with a history of cervical cancer [J].
Bergmark, K ;
Åvall-Lundqvist, E ;
Dickman, PW ;
Henningsohn, L ;
Steineck, G .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (18) :1383-1389
[3]   A prospective study of quality of life in head and neck cancer patients.: Part II:: Longitudinal data [J].
Bjordal, K ;
Ahlner-Elmqvist, M ;
Hammerlid, E ;
Boysen, M ;
Evensen, JF ;
Biörklund, A ;
Jannert, M ;
Westin, T ;
Kaasa, S .
LARYNGOSCOPE, 2001, 111 (08) :1440-1452
[4]   A 12 country field study of the EORTC QLQ-C30 (version 3.0) and the head and neck cancer specific module (EORTC QLQ-H&N35) in head and neck patients [J].
Bjordal, K ;
de Graeff, A ;
Fayers, PM ;
Hammerlid, E ;
van Pottelsberghe, C ;
Curran, D ;
Ahlner-Elmqvist, M ;
Maher, EJ ;
Meyza, JW ;
Brédart, A ;
Söderholm, AL ;
Arraras, JJ ;
Feine, JS ;
Abendstein, H ;
Morton, RP ;
Pignon, T ;
Huguenin, P ;
Bottomly, A ;
Kaasa, S .
EUROPEAN JOURNAL OF CANCER, 2000, 36 (14) :1796-1807
[5]  
Bukovic D, 2003, COLLEGIUM ANTROPOL, V27, P173
[6]   Assessing the impact of late treatment effects in cervical cancer: an exploratory study of women's sexuality [J].
Burns, M. ;
Costello, J. ;
Ryan-Woolley, B. ;
Davidson, S. .
EUROPEAN JOURNAL OF CANCER CARE, 2007, 16 (04) :364-372
[7]   Outcomes of hysterectomy [J].
Carlson, KJ .
CLINICAL OBSTETRICS AND GYNECOLOGY, 1997, 40 (04) :939-946
[8]   Quality of life of lung cancer patients: Validation of the Taiwan Chinese version of the EORTC QLQ-C30 and QLQ-LC13 [J].
Chie, WC ;
Yang, CH ;
Hsu, C ;
Yang, PC .
QUALITY OF LIFE RESEARCH, 2004, 13 (01) :257-262
[9]   Quality of life in patients of nasopharyngeal carcinoma: Validation of the Taiwan Chinese version of the EORTC QLQ-C30 and the EORTC QLQ-H&N35 [J].
Chie, WC ;
Hong, RL ;
Lai, CC ;
Ting, LL ;
Hsu, MM .
QUALITY OF LIFE RESEARCH, 2003, 12 (01) :93-98
[10]  
Classen J, 1998, STRAHLENTHER ONKOL, V174, P82