Sonothrombolysis with magnetic microbubbles under a rotational magnetic field

被引：42

作者：

Zhang, Bohua ^{[1
]}

Kim, Howuk ^{[1
]}

Wu, Huaiyu ^{[1
]}

Gao, Yu ^{[2
]}

Jiang, Xiaoning ^{[1
]}

机构：

[1] North Carolina State Univ, Dept Mech & Aerosp Engn, Raleigh, NC 27695 USA

[2] Nanjing Univ Posts & Telecommun, Inst Adv Mat, Nanjing 210023, Jiangsu, Peoples R China

来源：

ULTRASONICS | 2019年 / 98卷

基金：

美国国家卫生研究院;

关键词：

Magnetic microbubbles; Magnetic nanoparticle; Thrombolysis; Sonothrombolysis; Cavitation; TARGETED MICROBUBBLES; ISCHEMIC-STROKE; DRUG-DELIVERY; IN-VIVO; NANOPARTICLES; THROMBOLYSIS; OXIDE;

D O I：

10.1016/j.ultras.2019.06.004

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

Thrombosis is an extremely critical clinical condition where a clot forms inside a blood vessel which blocks the blood flow through the cardiovascular system. Previous sonothrombolysis methods using ultrasound and microbubbles (MBs) often have a relatively low lysis rate due to the low microbubbles concentration at clot region caused by blood flow in the vessel. To solve this problem, the magnetic microbubbles (MMBs) that can be retained by an outer magnetic field against blood flow are used in this study. Here we report the development of a new method using the rotational magnetic field to trap and vibrate magnetic microbubbles at target clot region and then using an intravascular forward-looking ultrasound transducer to activate them acoustically. In this study, we investigated the influence of different blood flow conditions, vessel occlusion conditions (partial and fully occluded), clot ages (fresh, retracted), ultrasound parameters (input voltage, duty cycle) and rotational magnetic field parameters (amplitude, frequency) on the thrombolysis rate. The results showed that the additional use of magnetic microbubbles significantly enhances in vitro lysis of blood clot.

引用

页码：62 / 71

页数：10

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