Oxidative radical cascade cyclization involving C(sp3)-C(sp3), C(sp3)-C(sp2) and C(sp2)-N bonds formation: direct construction of cyano and methyl substituted polyheterocycles

被引：36

作者：

Shang, Jia-Qi ^{[1
]}

Wang, Shi-Sheng ^{[1
]}

Fu, Hong ^{[1
]}

Li, Yi ^{[1
]}

Yang, Tao ^{[1
]}

Li, Ya-Min ^{[1
]}

机构：

[1] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming 650500, Yunnan, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2018年 / 5卷 / 12期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; DIRECT ALPHA-ARYLATION; ADDITION/CYCLIZATION CASCADE; PHOTOREDOX CATALYSIS; ALKYL NITRILES; ARYL HALIDES; UNACTIVATED ALKENES; ACETONITRILE; CYANOMETHYLATION; QUINOLINE-2,4(1H,3H)-DIONES;

D O I：

10.1039/c8qo00336j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An oxidative radical cascade cyclization of 2-cyano-3-arylaniline derived acrylamides with acetonitrile has been developed. The reaction provides a straightforward and practical access to cyano substituted pyrido[4,3,2-gh]phenanthridines, and exhibits a good functional group tolerance. Furthermore, such methyl substituted polyheterocycles were also obtained through a similar radical cascade.

引用

页码：1945 / 1949

页数：5

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