Upregulation of RAGE at the Blood-Brain Barrier in Streptozotocin-Induced Diabetic Mice
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作者:
Liu, Li Ping
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Anhui Med Univ, Affiliated Hosp 1, Dept Pharm, Hefei 230036, Peoples R ChinaChina Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R China
Liu, Li Ping
[3
]
Hong, Hao
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China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R China
Hong, Hao
[1
]
Liao, Jian Ming
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China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R China
Liao, Jian Ming
[2
]
Wang, Tong Sheng
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Anhui Med Univ, Affiliated Hosp 1, Dept Pharm, Hefei 230036, Peoples R ChinaChina Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R China
Wang, Tong Sheng
[3
]
Wu, Jing
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China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R China
Wu, Jing
[1
]
Chen, Si Si
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China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R China
Chen, Si Si
[1
]
Li, Yong Qi
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China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R China
Li, Yong Qi
[1
]
Long, Yan
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China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R China
Long, Yan
[1
]
Xia, Yuan Zheng
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China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R ChinaChina Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R China
Xia, Yuan Zheng
[1
]
机构:
[1] China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Peoples R China
[2] China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 210009, Peoples R China
[3] Anhui Med Univ, Affiliated Hosp 1, Dept Pharm, Hefei 230036, Peoples R China
Deposition of amyloid-beta peptide (A beta) in the brain of diabetes is poorly understood. The receptor for advanced glycation end products (RAGE) at the blood-brain barrier (BBB) is critical for regulation of A beta homeostasis in the brain. In this studies, we used streptozotocin-induced diabetic mice to observe the expression of RAGE at the BBB by Western blot and immunocytochemical analysis, and the in vivo blood-to-brain influx transport of I-125-A beta(1-40) using the permeability surface area product (PS) and brain capillary uptake. In the diabetic mice with hyperglycemia (>16.0 mmol/L) at 6 weeks, RAGE expression at the BBB was significantly upregulated, no significant changes of RAGE levels were found at 1 and 3 weeks after diabetes induction. The data of PS and brain capillary uptake for A beta showed significant RAGE-dependent transport of A beta across the BBB and substantial RAGE-dependent brain capillary uptake at 6 weeks after diabetes induction. We conclude that the upregulation of RAGE at the BBB contributes to cerebral A beta deposition in the diabetes. Synapse 63:636-642,2009. (c) 2009 Wiley-Liss, Inc.
机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Deane, R
Yan, SD
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Yan, SD
Submamaryan, RK
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Submamaryan, RK
LaRue, B
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LaRue, B
Jovanovic, S
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Jovanovic, S
Hogg, E
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Hogg, E
Welch, D
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Welch, D
Manness, L
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Manness, L
Lin, C
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Lin, C
Yu, J
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Yu, J
Zhu, H
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Zhu, H
Ghiso, J
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Ghiso, J
Frangione, B
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Frangione, B
Stern, A
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Stern, A
Schmidt, AM
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Schmidt, AM
Armstrong, DL
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Armstrong, DL
Arnold, B
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Arnold, B
Liliensiek, B
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Liliensiek, B
Nawroth, P
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Nawroth, P
Hofman, F
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Hofman, F
Kindy, M
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Kindy, M
Stern, D
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Stern, D
Zlokovic, B
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Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USAUniv Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
机构:
Univ Rochester, Med Ctr, Frank P Smith Lab Neurosci & Neurosurg Res, Rochester, NY 14642 USAUniv Rochester, Med Ctr, Frank P Smith Lab Neurosci & Neurosurg Res, Rochester, NY 14642 USA
Deane, Rashid
Zlokovic, Berislav V.
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Univ Rochester, Med Ctr, Frank P Smith Lab Neurosci & Neurosurg Res, Rochester, NY 14642 USAUniv Rochester, Med Ctr, Frank P Smith Lab Neurosci & Neurosurg Res, Rochester, NY 14642 USA
机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Deane, R
Yan, SD
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Yan, SD
Submamaryan, RK
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Submamaryan, RK
LaRue, B
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
LaRue, B
Jovanovic, S
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Jovanovic, S
Hogg, E
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Hogg, E
Welch, D
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Welch, D
Manness, L
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Manness, L
Lin, C
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h-index: 0
机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Lin, C
Yu, J
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h-index: 0
机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Yu, J
Zhu, H
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h-index: 0
机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Zhu, H
Ghiso, J
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Ghiso, J
Frangione, B
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Frangione, B
Stern, A
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Stern, A
Schmidt, AM
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Schmidt, AM
Armstrong, DL
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Armstrong, DL
Arnold, B
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Arnold, B
Liliensiek, B
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h-index: 0
机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Liliensiek, B
Nawroth, P
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Nawroth, P
Hofman, F
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机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Hofman, F
Kindy, M
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h-index: 0
机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Kindy, M
Stern, D
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h-index: 0
机构:Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
Stern, D
Zlokovic, B
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机构:
Univ Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USAUniv Rochester, Med Ctr, Dept Neurosurg, Frank P Smith Labs Neurosurg, Rochester, NY 14642 USA
机构:
Univ Rochester, Med Ctr, Frank P Smith Lab Neurosci & Neurosurg Res, Rochester, NY 14642 USAUniv Rochester, Med Ctr, Frank P Smith Lab Neurosci & Neurosurg Res, Rochester, NY 14642 USA
Deane, Rashid
Zlokovic, Berislav V.
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Univ Rochester, Med Ctr, Frank P Smith Lab Neurosci & Neurosurg Res, Rochester, NY 14642 USAUniv Rochester, Med Ctr, Frank P Smith Lab Neurosci & Neurosurg Res, Rochester, NY 14642 USA