Novel Therapeutic Approaches for Epstein-Barr Virus Associated Gastric Cancer

被引：17

作者：

Kang, Byung Woog ^{[1
]}

Baek, Dong Won ^{[1
]}

Kang, Hyojeung ^{[2
]}

Baek, Jin Ho ^{[1
]}

Kim, Jong Gwang ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Canc Res Inst, Chilgok Hosp, Dept Oncol Hematol,Sch Med, Daegu, South Korea

[2] Kyungpook Natl Univ, Coll Pharm, Daegu, South Korea

来源：

ANTICANCER RESEARCH | 2019年 / 39卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

Epstein-Barr virus; gastric cancer; treatment; review; GASTROESOPHAGEAL JUNCTION CANCER; ISLAND METHYLATOR PHENOTYPE; PI3K PATHWAY; DOUBLE-BLIND; PI3K/AKT/MTOR PATHWAY; PHASE-I; EXPRESSION; CARCINOMA; GENE; ADENOCARCINOMA;

D O I：

10.21873/anticanres.13555

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epstein-Barr virus (EBV)-associated gastric cancer (GC) (EBVaGC) is classified as one of four GC subtypes by comprehensive molecular characterization. Though the mechanism of tumorigenesis by EBV infection has not yet been fully clarified, EBV infection might contribute to the malignant transformation of GC cells by involving various cellular processes and signaling pathways. EBVaGC has shown the following distinct characteristics in contrast to other subtypes: extreme DNA hypermethylation, recurrent phosphatidylinositol 4,5-biphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) mutations, overexpression of programmed cell death ligand 1/2 (PD-L1/2), and occasional immune cell signaling activation. Therefore, using these molecular features as guides, targeted agents need to be evaluated in clinical trials for EBVaGC. Accordingly, this review uses the best available evidence to focus on novel therapeutic approaches using the distinct pathologic characteristics of EBVaGC patients.

引用

页码：4003 / 4010

页数：8

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