Phosphatidylinositol 3-kinase - A key regulator of vascular tone?

被引:36
作者
Sata, M [1 ]
Nagai, R [1 ]
机构
[1] Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Bunkyo Ku, Tokyo 1138655, Japan
关键词
phosphatidylinositol; 3-kinase; Akt; hypertension; smooth muscle; endothelial cells;
D O I
10.1161/01.RES.0000031956.29928.62
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:273 / 275
页数:3
相关论文
共 25 条
  • [1] Regulation of vascular smooth muscle cell apoptosis - Modulation of bad by a phosphatidylinositol 3-kinase-dependent pathway
    Bai, HZ
    Pollman, MJ
    Inishi, Y
    Gibbons, GH
    [J]. CIRCULATION RESEARCH, 1999, 85 (03) : 229 - 237
  • [2] The phosphoinositide 3-kinase pathway
    Cantley, LC
    [J]. SCIENCE, 2002, 296 (5573) : 1655 - 1657
  • [3] Akt takes center stage in angiogenesis signaling
    Dimmeler, S
    Zeiher, AM
    [J]. CIRCULATION RESEARCH, 2000, 86 (01) : 4 - 5
  • [4] Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
    Dimmeler, S
    Fleming, I
    Fisslthaler, B
    Hermann, C
    Busse, R
    Zeiher, AM
    [J]. NATURE, 1999, 399 (6736) : 601 - 605
  • [5] Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells - Involvement in suppression of apoptosis
    Dimmeler, S
    Assmus, B
    Hermann, C
    Haendeler, J
    Zeiher, AM
    [J]. CIRCULATION RESEARCH, 1998, 83 (03) : 334 - 341
  • [6] HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway
    Dimmeler, S
    Aicher, A
    Vasa, M
    Mildner-Rihm, C
    Adler, K
    Tiemann, M
    Rütten, H
    Fichtlscherer, S
    Martin, H
    Zeiher, AM
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (03) : 391 - 397
  • [7] Phosphatidylinositol 3-kinase is required for insulin-like growth Factor-I-Induced vascular smooth muscle cell proliferation and migration
    Duan, C
    Bauchat, JR
    Hsieh, T
    [J]. CIRCULATION RESEARCH, 2000, 86 (01) : 15 - 23
  • [8] Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner
    Fujio, Y
    Walsh, K
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (23) : 16349 - 16354
  • [9] Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
    Fulton, D
    Gratton, JP
    McCabe, TJ
    Fontana, J
    Fujio, Y
    Walsh, K
    Franke, TF
    Papapetropoulos, A
    Sessa, WC
    [J]. NATURE, 1999, 399 (6736) : 597 - 601
  • [10] Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase
    Hafezi-Moghadam, A
    Simoncini, T
    Yang, ZQ
    Limbourg, FP
    Plumier, JC
    Rebsamen, MC
    Hsieh, CM
    Chui, DS
    Thomas, KL
    Prorock, AJ
    Laubach, VE
    Moskowitz, MA
    French, BA
    Ley, K
    Liao, JK
    [J]. NATURE MEDICINE, 2002, 8 (05) : 473 - 479