Stereoselective synthesis of a tricyclic guanidinium model of cylindrospermopsin

被引：43

作者：

McAlpine, IJ ^{[1
]}

Armstrong, RW ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 12期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

cylindrospermopsin; guanidines; piperidines;

D O I：

10.1016/S0040-4039(99)02348-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An 11-step enantioselective synthesis of the A-ring of cylindrospermopsin is described using an intramolecular conjugate addition as the key step to forming the piperidine ring. Further elaboration generates a tricyclic guanidine via a sequential double displacement strategy as a model for the cylindrospermopsin guanidinium core. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：1849 / 1853

页数：5

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