Prognostic Value of Grading Masticator Space Involvement in Nasopharyngeal Carcinoma according to MR Imaging Findings

被引：22

作者：

Zhang, Guo-Yi ^{[1
]}

Huang, Ying ^{[2
]}

Cai, Xiu-Yu ^{[3
]}

Chen, Xiang-Ping ^{[1
]}

Xu, Tao ^{[1
]}

Wu, Jing ^{[1
]}

Wei, Wei-Hong ^{[1
]}

Liu, Li-Zhi ^{[4
]}

Huang, Ze-Li ^{[1
]}

Zhou, Miao-Miao ^{[1
]}

Xia, Shi-Tong ^{[1
]}

Wang, Yue-Jian ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Foshan Hosp, Ctr Canc, Canc Res Inst, Foshan 528000, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Dept Radiat Oncol, Guangzhou 510275, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Dept VIP Reg, Guangzhou 510275, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, State Key Lab Oncol Southern China, Ctr Canc, Imaging Diag & Intervent Ctr, Guangzhou 510275, Guangdong, Peoples R China

来源：

RADIOLOGY | 2014年 / 273卷 / 01期

关键词：

INTENSITY-MODULATED RADIOTHERAPY; CONVENTIONAL 2-DIMENSIONAL RADIOTHERAPY; PARAPHARYNGEAL SPACE; PARANASOPHARYNGEAL EXTENSION; LOCAL-CONTROL; TOMOGRAPHY; METASTASIS; EXPERIENCE;

D O I：

10.1148/radiol.14132745

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Purpose: To derive a suitable method for grading masticator space invasion in nasopharyngeal carcinoma on the basis of magnetic resonance (MR) images and to determine its prognostic value in patients undergoing intensity-modulated radiation therapy. Materials and Methods: After institutional review board approval and informed consent were acquired, 808 patients with nasopharyngeal carcinoma who were treated with definitive intensity-modulated radiation therapy were analyzed retrospectively. The anatomic sites of masticator space involvement were identified with MR imaging. Overall survival, local relapse-free survival, and distant metastasis-free survival were calculated by using the Kaplan-Meier method and were compared by using the log-rank test. Potential prognostic factors were identified by means of multivariate analysis. Results: Masticator space involvement was diagnosed in 163 of 808 patients (20.2%). Patients with lateral invasion (involvement of the lateral pterygoid muscle of the masticator space and beyond) had significantly poorer overall survival and distant metastasis-free survival than those with medial invasion (involvement of the medial pterygoid muscle of the masticator space) (P = .035 and P = .026, respectively). Furthermore, their overall survival, local relapse-free survival, and distant metastasis-free survival were significantly poorer compared with patients with stage T2 or T3 disease (all P < .023) but similar to patients with stage T4 disease. The grade of masticator space involvement was an independent prognostic factor for overall survival, local relapse-free survival, and distant metastasis-free survival (all P < .023). Conclusion: Masticator space involvement in nasopharyngeal carcinoma should be graded as medial (stage T2 disease) or lateral (stage T4 disease). This can facilitate staging of nasopharyngeal carcinoma and may be a suitable prognostic indicator of survival. (C) RSNA, 2014

引用

页码：136 / 143

页数：8

共 26 条

[1]

Chua DTT, 1996, CANCER, V78, P202, DOI 10.1002/(SICI)1097-0142(19960715)78:2<202::AID-CNCR3>3.0.CO

[2]

2-N

[3] A COEFFICIENT OF AGREEMENT FOR NOMINAL SCALES [J].

COHEN, J .

EDUCATIONAL AND PSYCHOLOGICAL MEASUREMENT, 1960, 20 (01) :37-46

[4]

COX DR, 1972, J R STAT SOC B, V34, P187

[5] SEPARATION OF THE MASTICATOR SPACE FROM THE PARAPHARYNGEAL SPACE [J].

CURTIN, HD .

RADIOLOGY, 1987, 163 (01) :195-204

[6]

Edge SB, 2010, AJCC CANC STAGING HD, P63

[7]

Fleming ID, 1997, AJCC CANC STAGING MA, P31

[8]

Greene FL, 2002, AJCC CANC STAGING HD, P47

[9] Imaging Evaluation of the Parapharyngeal Space [J].

Gupta, Ajay ;

Chazen, J. Levi ;

Phillips, C. Douglas .

OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA, 2012, 45 (06) :1223-+

[10]

Heng DMK, 1999, CANCER-AM CANCER SOC, V86, P1912, DOI 10.1002/(SICI)1097-0142(19991115)86:10<1912::AID-CNCR6>3.0.CO

← 1 2 3 →